血脂联素和肿瘤坏死因子-α与原发性高血压的关系

被引:4
作者
朱志耘
机构
[1] 广州医学院第二附属医院内科
关键词
脂联素; 肿瘤坏死因子-α; 原发性高血压;
D O I
暂无
中图分类号
R544.1 [高血压];
学科分类号
100201 [内科学];
摘要
目的检测原发性高血压(essential hypertension,EH)患者血浆中脂联素(adiponectin)和肿瘤坏死因子-α(TNF-α),探讨脂联素和TNF-α与EH的关系。方法67例新发现且未经过治疗的轻、中度EH患者和42例正常人,记录年龄、性别,检测体重指数(BMI)、空腹血糖(FPG)、血脂谱及血压,用放射免疫分析法测定空腹胰岛素(FINS)、血浆脂联素及TNF-α水平。结果①EH组血浆脂联素水平为(17.05±3.08)ng/ml,对照组为(23.05±3.08)ng/ml,EH组较对照组显著降低(P<0.01)。②EH组血浆TNF-α水平为(26.55±2.55)fmol/ml,显著低于对照组(24.62±2.70)fmol/ml(P<0.01)。③Pearson相关分析表明,EH组血浆脂联素水平与TNF-α、年龄、PP及SBP呈显著负相关(P<0.05)。结论低脂联素血症、炎症因子共同作用,可能部分参与了EH的发病过程。
引用
收藏
页码:16 / 19
页数:4
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