柑橘黄酮川陈皮素的抗肿瘤作用研究

被引：58

作者：

王光凤 ^{[1
]}

王小晨 ^{[1
]}

肖璘 ^{[1
]}

周自桂 ^{[2
]}

郭彦飞 ^{[2
]}

刘珉宇 ^{[1
]}

刘英 ^{[1
]}

刘全海 ^{[1
]}

机构：

[1] 上海医药工业研究院

[2] 南京神州佳美药物研究有限公司

来源：

中草药 | 2007年 / 11期

关键词：

川陈皮素; 抗肿瘤作用; 协同作用;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的研究橘皮中提取的黄酮化合物川陈皮素的抗肿瘤作用:抑制小鼠移植瘤生长、与化疗药物的协同及抗肿瘤转移作用。方法采用多种肿瘤模型,川陈皮素ig给药。结果川陈皮素8～32mg/kg剂量对小鼠黑色素瘤B16的抑瘤率为42.24%～65.95%;对小鼠Lewis肺癌的抑瘤率为38.84%～59.09%;对小鼠S180肉瘤的抑瘤率为36.02%～45.98%。川陈皮素与小剂量的紫杉醇、丝裂霉素(MMC)、5-氟尿嘧啶(5-Fu)、顺铂(DDP)和阿霉素(ADR)联合用药时,表现明显的协同效应。川陈皮素对小鼠Lewis肺癌腋皮下接种肺转移的抑制率为33.63%～38.94%;对小鼠Colon26结肠癌腹腔接种腹膜转移的抑制率为37.74%～43.40%。结论川陈皮素具有一定的抗肿瘤生长作用,与临床常用化疗药物有协同作用,并可有效抑制实验性肿瘤转移。

引用

页码：1694 / 1697

页数：4

共 6 条

[1]

Anti‐tumour effects of nobiletin; a citrus flavonoid; on gastric cancer include: antiproliferative effects; induction of apoptosis and cell cycle deregulation.[J].N.Yoshimizu;Y.Otani;Y.Saikawa;T.Kubota;M.Yoshida;T.Furukawa;K.Kumai;K.Kameyama;M.Fujii;M.Yano;T.Sato;A.Ito;M.Kitajima.Alimentary Pharmacology & Therapeutics.2004,

[2]

Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages [J].

Lin, N ;

Sato, T ;

Takayama, Y ;

Mimaki, Y ;

Sashida, Y ;

Yano, M ;

Ito, A .

BIOCHEMICAL PHARMACOLOGY, 2003, 65 (12) :2065-2071

[3]

Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells [J].

Zheng, Q ;

Hirose, Y ;

Yoshimi, N ;

Murakami, A ;

Koshimizu, K ;

Ohigashi, H ;

Sakata, K ;

Matsumoto, Y ;

Sayama, Y ;

Mori, H .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2002, 128 (10) :539-546

[4]

Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro [J].

Rooprai, HK ;

Kandanearatchi, A ;

Maidment, SL ;

Christidou, M ;

Trillo-Pazos, G ;

Dexter, DT ;

Rucklidge, GJ ;

Widmer, W ;

Pilkington, GJ .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2001, 27 (01) :29-39

[5]

Cancer chemopreventive activity of 3,5,6,7,8,3′,4′-heptamethoxyflavone from the peel of citrus plants [J].

Iwase, Y ;

Takemura, Y ;

Ju-ichi, M ;

Yano, M ;

Ito, C ;

Furukawa, H ;

Mukainaka, T ;

Kuchide, M ;

Tokuda, H ;

Nishino, H .

CANCER LETTERS, 2001, 163 (01) :7-9

[6]

Inhibitory effect of flavonoids from Citrus plants on Epstein–Barr virus activation and two-stage carcinogenesis of skin tumors.[J].Yukiko Iwase;Yuko Takemura;Motoharu Ju-ichi;Chihiro Ito;Hiroshi Furukawa;Satoru Kawaii;Masamichi Yano;Xiao Yang Mou;Junko Takayasu;Harukuni Tokuda;Hoyoku Nishino.Cancer Letters.2000, 1

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