黄芪多糖对糖尿病鼠T细胞亚群的免疫调节作用

被引：48

作者：

陈蔚

李益明

俞茂华

施小梅

机构：

[1] 复旦大学附属华山医院老年科

来源：

中国现代医学杂志 | 2007年 / 01期

关键词：

黄芪多糖; 1型糖尿病; 免疫; 细胞因子;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

摘要：

目的探讨黄芪多糖(APS)对NOD小鼠T细胞亚群的免疫调节机制。方法观察APS组和对照组NOD鼠胰岛浸润淋巴细胞免疫组化、脾T淋巴细胞CD4+/CD8+亚群比值,RT-PCR法检测两组胰岛中IL-1β、IL-2、IL-6、IL-12、TNF-α和INF-γTh1型细胞因子的mRNA表达。结果APS可以降低NOD小鼠1型糖尿病的发病率,下降胰岛浸润炎症细胞及脾脏中的CD4+/CD8+亚群比值。与对照组相比,APS组胰岛IL-1β、IL-2、IL-6、IL-12、TNF-α和INF-γ的mRNA表达水平明显下调。结论APS能纠正NOD小鼠Th1型细胞/细胞因子的免疫失衡状态,预防1型糖尿病的发生。

引用

页码：28 / 31+35 +35

页数：5

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