血管内皮生长因子与育龄妇女卵巢血流和功能关系的研究

被引：6

作者：

季慧玲

邵敬於

陆惠娟

凌梅立

周剑萍

机构：

[1] 上海市第一妇婴保健院

[2] 复旦大学医学院妇产科医院上海

[3] 上海

来源：

现代妇产科进展 | 2002年 / 03期

关键词：

血管内皮生长因子; 卵巢血流; 卵巢功能;

D O I：

10.13283/j.cnki.xdfckjz.2002.03.012

中图分类号：

R711 [妇科学];

学科分类号：

100211 ;

摘要：

目的:探讨育龄妇女卵巢VEGF表达与E2、P分泌、卵巢血流、血清VEGF水平的关系。方法:选择19例卵巢功能正常的子宫肌瘤育龄妇女患者,应用多普勒超声测定优势卵泡所在侧卵巢内血流阻力指数、搏动指数、收缩峰值血流速度（PSV）;用 ELISA法测定血清VEGI水平;用放射免疫双抗法测定血清比P水平;用免疫组化法测定优势卵泡或黄体VEGF表达强度。结果:（1）卵巢VEGF表达在整个月经周期与血E2水平呈显著正相关（r=0.502,P<0.05）,在黄体期与血清P水平呈显著正相关（r=0.837,P<0.01）。整个月经周期内血清VEGF水平与血清E2浓度无相关性（P>0.05）,黄体期血清VECF水平与血清E2、P浓度呈正相关（r分别为0.565和0.625,P<0.05）;（2）卵巢VEGF表达与优势卵巢内血流搏动指数、阻力指数呈负相关（r分别为-0.615和-0.646,P均<0.05）;（3）育龄妇女卵巢VEGF表达强度与血清VEGF水平呈显著正相关（r=0.720,P<0.01）。结论:卵巢VEGF表达与E2、P分泌功能有关,其机理可能是通过旁分泌和自分泌方式分别作用于血管内皮和性激素分泌细胞;卵巢VEGF表达与优势卵泡侧卵巢内血流有关;育龄妇女卵巢VEGF表达与血清VEGF浓度呈显著正相关,卵巢是影响育龄妇女血清VEGF水平的主要器官之一。

引用

页码：194 / 197

页数：4

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