NMDA受体与癫痫发病机制的研究现状

被引：5

作者：

来海欧

杨金升

机构：

[1] 兰州军区兰州总医院神经内科

来源：

国际神经病学神经外科学杂志 | 2008年 / 01期

关键词：

N-甲基-D-天门冬氨酸受体; N-甲基-D-冬氨酸受体亚单位2B阻滞剂; 艾芬地尔; 发病机制;

D O I：

10.16636/j.cnki.jinn.2008.01.011

中图分类号：

R742.1 [癫痫];

学科分类号：

1002 ;

摘要：

癫痫的主要机制为脑内兴奋性氨基酸活性升高。在癫痫发作中,N-甲基-D-天门冬氨酸(NMDA)受体含量增多,表达升高,且其各个亚型之间相互作用,构形发生变化,使突触后膜支架蛋白磷酸化,发生级联发应,使NMDA受体配体离子通道持续开放,神经元持续放电,并向周围神经元放散扩布;长期癫痫反复发作,导致苔藓纤维发芽,神经元缺失;这些形态学和电生理改变,反之,导致癫痫的易感和反复发作。通过多年动物实验和临床应用,提示N-甲基-D-冬氨酸受体亚单位2B(NR2B),高选择性的拮抗剂有广阔的临床应用前景。

引用

页码：72 / 76

页数：5

共 7 条

[1] Alterations of NR2B and PSD-95 expression after early-life epileptiform discharges in developing neurons [J].

Jiang, Qian ;

Wang, Jingmin ;

Wu, Xiru ;

Jiang, Yuwu .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2007, 25 (03) :165-170

[2]

NR2B antagonists restrict spatiotemporal spread of activity in a rat model of cortical dysplasia[J] . Susanta Bandyopadhyay,John J. Hablitz.Epilepsy Research . 2006 (2)

[3]

NR3 protein expression in trigeminal neurons during postnatal development[J] . Kohji Ishihama,Jack E. Turman.Brain Research . 2006 (1)

[4] Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus [J].

Huo, Jeanne Zhen ;

Dykstra, Crystal M. ;

Gurd, James W. .

NEUROSCIENCE LETTERS, 2006, 401 (03) :266-270

[5]

Effects of distinct classes of N -methyl- d -aspartate receptor antagonists on seizures, axonal sprouting and neuronal loss in vitro: suppression by NR2B-selective antagonists[J] . Xiao-Min Wang,Suzanne B. Bausch.Neuropharmacology . 2004 (7)

[6] Long-term effects of seizures in neonatal rats on spatial learning ability and N-methyl-D-aspartate receptor expression in the brain [J].

Bo, T ;

Jiang, YW ;

Cao, HY ;

Wang, JM ;

Wu, XR .

DEVELOPMENTAL BRAIN RESEARCH, 2004, 152 (02) :137-142

[7]

The Role of N-Methyl-d-Aspartate (NMDA) Receptors in Pain: A Review[J] . Andrei B. Petrenko,Tomohiro Yamakura,Hiroshi Baba,Koki Shimoji.Anesthesia & Analgesia . 2003 (4)

← 1 →