低频rTMS联合作业疗法在缺血性脑卒中恢复期中的应用

被引：11

作者：

孔培培 ^{[1
]}

陈颖 ^{[1
]}

翟清华 ^{[1
]}

许梦雅 ^{[1
]}

铁新琴 ^{[2
]}

王静 ^{[1
]}

机构：

[1] 郑州大学第二附属医院神经康复科

[2] 郑州大学第三附属医院

来源：

中国实用神经疾病杂志 | 2019年 / 22卷 / 03期

关键词：

rTMS; 作业疗法; 缺血性脑卒中恢复期; NGF; BDNF; MMSE; FMA; MEP; CMCT;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

100204 [神经病学];

摘要：

目的探讨低频rTMS(重复经颅磁刺激)联合作业疗法在缺血性脑卒中恢复期患者中的应用效果。方法选取郑州大学第二附属医院2016-10—2018-06收冶的缺血性脑卒中恢复期患者98例为研究对象,按随机数字表法分为对照组(n=49)与研究组(n=49)。对照组采取作业疗法,研究组于对照组基础上采取低频rTMS,均持续干预3个月。统计2组干预前及干预3个月后认知功能(MMSE)及肢体运动功能(Fugl-Meyer)评分、运动诱导电位(MEP)、中枢传导时间(CMCT)、血清神经生长因子(NGF)、脑源性神经营养因子(BDNF)水平及执行能力(BADS)评分。结果 (1)认知及肢体运动功能:干预3个月后2组MMSE及FMA评分均较干预前增高,研究组高于对照组(P<0.05);(2)MEP及CMCT:2组MEP及CMCT均较干预前减少,研究组少于对照组(P<0.05);(3)血清神经细胞因子:2组血清NGF及BDNF水平均较干预前增高,研究组高于对照组(P<0.05);(4)执行能力:2组BADS评分均较干预前增高,研究组高于对照组(P<0.05)。结论联合采取作业疗法及低频rTMS对缺血性脑卒中恢复期患者实施干预,可增加血清神经细胞因子含量,利于改善其认知功能与肢体运动功能,并提升其执行能力。

引用

页码：238 / 245

页数：8

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