吲哚胺-2,3-双加氧酶IDO1抑制剂研究进展

被引：8

作者：

徐跃洋 ^{[1
]}

吴俊军 ^{[2
]}

机构：

[1] 北京凯得尔森生物技术有限公司

[2] 湖北文理学院化学与食品学院

来源：

中国新药杂志 | 2016年 / 25卷 / 04期

关键词：

吲哚胺-2,3-双加氧酶1; IDO1; 抑制剂; 肿瘤; 疾病治疗;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

IDO1(吲哚胺-2,3-双加氧酶1)催化细胞内色氨酸反应生成犬尿氨酸。在抗原递呈细胞及多种肿瘤组织中,IDO1表达水平异常升高,肿瘤细胞可能借助IDO1而免于被免疫系统清除,产生免疫耐受。研究表明indoximod等IDO1抑制剂能够抑制IDO1通路,并逆转IDO1介导的免疫抑制,最终达到抑制肿瘤生长的目的。目前,已经有很多IDO1抑制剂的相关报道,其中部分IDO1抑制剂具有较好的IDO1选择性及抑制活性,少数已经进入了临床阶段。这些IDO1抑制剂在产生疗效的同时,也导致了一些不良反应的发生。本文将对IDO1及其抑制剂研究状况进行概述,以推进现有IDO1抑制剂的改良及新抑制剂的开发。

引用

页码：425 / 432

页数：8

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