辅助性T细胞及调节性B细胞在溃疡性结肠炎发病机制中的作用

被引：4

作者：

徐毅晖

陈垦

崔淑兰

王晖

机构：

[1] 广东药学院临床医学院内科教研室

来源：

中华消化杂志 | 2011年 / 10期

关键词：

D O I：

暂无

中图分类号：

R574.62 [结肠疾病];

学科分类号：

100201 [内科学];

摘要：

<正>炎症性肠病(inflammatory bowel disease,IBD)患病率在国内外均呈上升趋势,已成为消化系统的常见疾病。IBD的病因和发病机制尚未完全明确,目前认为主要包括环境、遗传、感染和免疫等因素。大量研究表明,肠道黏膜免疫反应异常激活是导致IBD发生、发展和转归的直接原因。其中Th1/Th2失衡一直被认为是IBD发病机制之一,而对于溃疡性结肠炎(UC),有学者认为与Th2关系较为密切,亦有人认为是Th1和Th2共同作用的结果。而Th17的发现解释了传统Th1/Th2轴异常现象发生的原

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