糖尿病肾病发病机制研究进展

被引：131

作者：

赵龙

关广聚

机构：

[1] 山东大学第二医院肾内科

来源：

中华肾脏病杂志 | 2013年 / 29卷 / 07期

关键词：

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症];

学科分类号：

100201 [内科学];

摘要：

<正>在糖尿病人群中糖尿病肾病（DN）发病率约为20%40%,是糖尿病的主要并发症和死亡原因。近年来随着糖尿病患者人数的快速增长,DN的发病率逐年上升,在一些国家或地区已经成为终末期肾病（ESRD）的首位原因。DN早期主要的病理改变为肾小球肥大,肾小球和肾小管基底膜的增厚及系膜区细胞外基质（ECM）的进行性聚积;后期是肾小球、肾小管间质纤维化,最终导致蛋白尿和肾衰竭。DN的发病机制复杂,其确切机制尚未明确,目前的研究结果提示代谢紊乱、血流动力学改变、炎性反应机制、细胞因子、氧化应激、遗传因素、激肽系统及自噬等多种因素参与了DN的发病。现将近年来有关DN发病机制的最新研究成果综述如下。

引用

共 25 条

[1]

Phenotypic change of macrophages in the progression of diabetic nephropathy; sialoadhesin-positive activated macrophages are increased in diabetic kidney [J].

Nagase, Ryo ;

Kajitani, Nobuo ;

Shikata, Kenichi ;

Ogawa, Daisuke ;

Kodera, Ryo ;

Okada, Shinichi ;

Kido, Yuichi ;

Makino, Hirofumi .

CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2012, 16 (05) :739-748

[2]

Exacerbation of diabetic nephropathy by hyperlipidaemia is mediated by Toll-like receptor 4 in mice [J].

Kuwabara, T. ;

Mori, K. ;

Mukoyama, M. ;

Kasahara, M. ;

Yokoi, H. ;

Saito, Y. ;

Ogawa, Y. ;

Imamaki, H. ;

Kawanishi, T. ;

Ishii, A. ;

Koga, K. ;

Mori, K. P. ;

Kato, Y. ;

Sugawara, A. ;

Nakao, K. .

DIABETOLOGIA, 2012, 55 (08) :2256-2266

[3]

Endothelial mesenchymal transformation mediated by IL-1β-induced FGF-2 in corneal endothelial cells.[J].Jeong Goo Lee;MinHee K. Ko;EunDuck P. Kay.Experimental Eye Research.2011, 1

[4]

Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy [J].

Zhou, T. ;

He, X. ;

Cheng, R. ;

Zhang, B. ;

Zhang, R. R. ;

Chen, Y. ;

Takahashi, Y. ;

Murray, A. R. ;

Lee, K. ;

Gao, G. ;

Ma, J-X. .

DIABETOLOGIA, 2012, 55 (01) :255-266

[5]

Allelic variations in superoxide dismutase-1 (SOD1) gene are associated with increased risk of diabetic nephropathy in type 1 diabetic subjects [J].

Mohammedi, Kamel ;

Maimaitiming, Suliya ;

Emery, Nathalie ;

Bellili-Munoz, Naima ;

Roussel, Ronan ;

Fumeron, Frederic ;

Hadjadj, Samy ;

Marre, Michel ;

Velho, Gilberto .

MOLECULAR GENETICS AND METABOLISM, 2011, 104 (04) :654-660

[6]

Genetic associations in diabetic nephropathy: a meta-analysis [J].

Mooyaart, A. L. ;

Valk, E. J. J. ;

van Es, L. A. ;

Bruijn, J. A. ;

de Heer, E. ;

Freedman, B. I. ;

Dekkers, O. M. ;

Baelde, H. J. .

DIABETOLOGIA, 2011, 54 (03) :544-553

[7]

A Glimpse of Various Pathogenetic Mechanisms of Diabetic Nephropathy.[J].Yashpal S. Kanwar;Lin Sun;Ping Xie;Fu-you Liu;Sheldon Chen.Annual Review of Pathology: Mechanisms of Disease.2011, 1

[8]

Dietary polyunsaturated fatty acids slow the progression of diabetic nephropathy in streptozotocin-induced diabetic rats [J].