甘肃省妇女宫颈HPV感染的流行病学特征

被引:24
作者
王燕
吴珍珍
周庆云
机构
[1] 甘肃省妇幼保健院
关键词
人乳头状瘤病毒; 基因型; 宫颈癌; 宫颈上皮内瘤样病变;
D O I
暂无
中图分类号
R737.33 [子宫肿瘤];
学科分类号
100214 ;
摘要
目的:了解甘肃地区健康妇女宫颈人乳头瘤病毒(human papillomavirus,HPV)感染的流行病学特征,探讨人乳头瘤病毒HPV的型别与病理分级的关系。方法:选择2009年5~8月在甘肃省妇幼保健院妇科门诊行宫颈HPV分型检测的576例患者为研究对象,采用核酸分子快速导流杂交基因芯片技术(Hybrimax)对所有患者宫颈脱落细胞进行HPV分型,随后进行阴道镜检查、宫颈多点活检和宫颈管诊刮术,以病理学诊断为金标准。结果:576例患者中,HPV阳性率19.44%,高危型占73.21%。不同宫颈病变中常见的HPV亚型(检出率>10.0%)从高到低依次为HPV16(26.12%)、HPV58(15.67%)、HPV52(10.45%)。不同病理分级中HPV型别不同,宫颈癌中依次为HPV16、18、31;CINⅡ及CINⅢ中依次为HPV16、58、31、33、66;CINⅠ中依次为HPV16、58、52、33、39、6、11、68、cp8304。对于病理诊断≥CINⅡ者,HPV分型检测的敏感度为79.31%,特异度为87.26%,阳性预测值为41.07%,阴性预测值为97.41%。结论:HPV基因分型检测,可1次检测多种亚型,了解HPV型别分布的地域性差异,对于研制适宜甘肃省妇女的特异性HPV疫苗有指导意义,且有利于宫颈病变的分级、分型及指导个体化治疗。
引用
收藏
页码:5371 / 5373
页数:3
相关论文
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