丙泊酚对急性肺损伤大鼠血红素氧合酶-1表达的影响

被引：5

作者：

王曾庚

杨春丽

聂祥碧

郭经华

杨小刚

机构：

[1] 江西省人民医院ICU

来源：

江西医药 | 2014年 / 49卷 / 05期

关键词：

丙泊酚; 急性肺损伤; 血红素氧合酶-1;

D O I：

暂无

中图分类号：

R563.8 [呼吸衰竭];

学科分类号：

100201 [内科学];

摘要：

目的探讨丙泊酚对肺的保护作用及其可能作用机制。方法通过尾静脉注射内毒素建立急性肺损伤模型,丙泊酚和锌原卟啉同样经过尾静脉给药。将Wistar大鼠随机分入实验对照组(C组)、脂多糖组(L组)、脂多糖+丙泊酚组(LP组)和锌原卟啉组(LZ组)。给药前及开始后第3、6和12h测定动脉血氧分压(PaO2),实验结束后观察肺湿/干重(W/D)比值、肺组织病理学检查并进行肺损伤轻重程度评分,同时观察各组大鼠肺组织血红素氧合酶-1(HO-1)含量。结果实验前各组PaO2无明显差异,注射LPS后L组PaO2持续下降,和C组相比其PaO2显著降低(P<0.05)。实验结束后L组和C组相比其W/D比值、肺组织病理学检查评分及HO-1含量显著增加(P<0.05)。而LP组和L组相比W/D比值、肺组织病理学检查评分含量显著降低(P<0.05),而PaO2和HO-1含量显著升高(P<0.05)。而LZ组加入锌原卟啉后明显抑制丙泊酚以上保护作用。结论丙泊酚具有肺保护作用,且该作用可能与其通过增加HO-1表达作用相关。

引用

页码：385 / 387

页数：3

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