骨关节炎神经病理性疼痛诊疗概述

被引：20

作者：

刘小立

机构：

[1] 河北医科大学第四医院

来源：

中国新药杂志 | 2015年 / 18期

关键词：

骨关节炎; 疼痛; 神经病理性疼痛; 诊疗;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

骨关节炎(osteoarthritis,OA)是最常见的关节炎,疼痛是OA最典型的症状,尽管应用各种保守和介入的治疗方法,但疼痛控制仍不理想。OA疼痛不单纯是感受伤害性或炎性,还有神经病理性机制或混合机制,这可能是导致顽固性疼痛的原因之一。对于OA疼痛患者,筛查与诊断神经病理性疼痛很重要,应当成为常规的检查和评估。对于OA神经病理性疼痛或有神经病理性疼痛表现者,应当按照神经病理性疼痛治疗,个体化和综合治疗。鉴于目前尚无治疗OA的有效方法,疼痛治疗是重要的组成部分,尤其是神经病理性疼痛或有神经病理性疼痛表现,并伴有其他精神、心理、行为异常者,需要联合治疗和综合治疗,以期缓解症状,改善功能,提高生活质量。

引用

页码：2073 / 2076

页数：4

共 13 条

[1]

神经病理性疼痛诊疗专家共识 [J].

神经病理性疼痛诊疗专家组 .

中国疼痛医学杂志, 2013, 19 (12) :705-710

[2]

神经病理性疼痛诊断量表[J] 陈向军; 中国现代神经疾病杂志 2013, 09

[3]

Osteoarthritis[J] S Glyn-Jones;A J R Palmer;R Agricola;A J Price;T L Vincent;H Weinans;A J Carr The Lancet 2015,

[4]

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis[J] Nanna B Finnerup;Nadine Attal;Simon Haroutounian;Ewan McNicol;Ralf Baron;Robert H Dworkin;Ian Gilron;Maija Haanpää;Per Hansson;Troels S Jensen;Peter R Kamerman;Karen Lund;Andrew Moore;Srinivasa N Raja;Andrew S C Rice;Michael Rowbotham;Emily Sena;Philip Siddall;Blair H Smith;Mark Wallace Lancet Neurology 2015,

[5]

Osteoarthritis joint pain: The cytokine connection[J] Rachel E. Miller;Richard J. Miller;Anne-Marie Malfait Cytokine 2014,

[6]

Neuropathic pain in osteoarthritis: A review of pathophysiological mechanisms and implications for treatment[J] Theodoros Dimitroulas;Rui V. Duarte;Asis Behura;George D. Kitas;Jon H. Raphael Seminars in Arthritis and Rheumatism 2014,

[7]

Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis[J] Go Ishikawa;Yukinori Nagakura;Nobuaki Takeshita;Yasuaki Shimizu European Journal of Pharmacology 2014,

[8]

Neuropathic pain symptoms in a community knee OA cohort[J] J.R. Hochman;L. Gagliese;A.M. Davis;G.A. Hawker Osteoarthritis and Cartilage 2011,

[9]

Neuropathic pain: diagnosis; pathophysiological mechanisms; and treatment[J] Ralf Baron;Andreas Binder;Gunnar Wasner Lancet Neurology 2010,

[10]

Psychological factors and their relation to osteoarthritis pain[J] B.L. Wise;J. Niu;Y. Zhang;N. Wang;J.M. Jordan;E. Choy;D.J. Hunter Osteoarthritis and Cartilage 2010,

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