心房颤动患者循环血浆肾素、血管紧张素Ⅱ和醛固酮的变化及临床意义

被引：23

作者：

王学东

贾三庆

胡大一

吴永全

邢云丽

陈金玲

杜立杰

机构：

[1] 北京仁和医院心内科

[2] 北京友谊医院心血管疾病诊治研究中心

[3] 北京大学人民医院心内科

[4] 北京仁和医院心内科北京

[5] 北京

[6] 北京

来源：

中国心血管杂志 | 2004年 / 05期

关键词：

心房颤动; 肾素; 血管紧张素Ⅱ; 醛固酮;

D O I：

暂无

中图分类号：

R541.75 [];

学科分类号：

摘要：

目的分析心房颤动患者循环血浆肾素、血管紧张素Ⅱ(AngⅡ)、醛固酮(Ald)的水平变化,并探讨其临床意义。方法入选42例患者,男19例,女23例,年龄37-80(63.02±10.66)岁。按有无心房颤动病史分为三组:窦性心律组(SR组)14例,阵发性心房颤动组(pAF组)15例,慢性心房颤动组(cAF组)13例。应用放射免疫方法测定循环血浆肾素、AngⅡ、Ald浓度。结果cAF组患者平均左心房直径与SR组和pAF、组相比明显增大(分别增大45.3％和31.8％,P<.01),而且cAF组患者循环血浆肾素、AngⅡ、Ald浓度与SR组相比明显升高(分别升高83.3％、61.7％、34.2％,P<0.01-0.02)。三组患者左心房直径与其循环血浆肾素、AngⅡ、Ald浓度变化具有明显的正相关关系(P<0.05-0.01)。结论心房颤动时存在肾素-血管紧张素系统(RAS)和Ald的激活。RAS和Ald可能参与了心房结构重构的发生。Ald的作用靶点可能主要是心房间质。

引用

页码：339 / 341+360 +360

页数：4

共 10 条

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