他汀类药物抗肿瘤研究进展

被引:7
作者
杨永长 [1 ]
黄文芳 [1 ]
卢贤瑜 [2 ]
机构
[1] 四川省医学科学院、四川省人民医院检验科
[2] 重庆医科大学医学检验系
关键词
降血脂药; 抗肿瘤药; 细胞凋亡;
D O I
暂无
中图分类号
R730.5 [肿瘤治疗学];
学科分类号
摘要
他汀类药物的抗肿瘤作用近年来备受关注。研究发现,他汀类药物能抑制肿瘤细胞增殖,诱导其分化或凋亡,而对正常细胞无明显毒副作用。体外实验证明,他汀类药物可抑制Ras、RhoGTPase和核纤层蛋白异戊二烯化,影响细胞周期进程和凋亡相关基因表达,抑制血管形成等。现综述他汀类药物抗肿瘤的国内外研究进展。
引用
收藏
页码:1031 / 1032+1035 +1035
页数:3
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