脂联素与PPARγ关系的研究进展

被引：7

作者：

王鸿燕

林朱森

邹大进

机构：

[1] 第二军医大学附属长海医院内分泌科

[2] 海军总医院急诊科

[3] 第二军医大学附属长海医院内分泌科上海

[4] 北京

[5] 上海

来源：

国外医学内分泌学分册. | 2004年 / 03期

关键词：

脂联素; 过氧化物酶体增殖物激活受体γ; 胰岛素抵抗;

D O I：

暂无

中图分类号：

R341 [];

学科分类号：

1001 ;

摘要：

脂联素是由脂肪细胞特异性分泌的激素,其血浆水平在肥胖症、2型糖尿病、冠心病等存在胰岛素抵抗的疾病中下降。过氧化物酶体增殖物激活受体γ(PPARγ)2的Prol2Ala多态性可导致PPARγ的转录活性下降,从而引起脂联素释放减少。PPARγ/维甲酸X受体异二聚体与脂联素基因中的功能性PPAR应答元件特异性结合而影响脂联素基因的转录。

引用

页码：181 / 183

页数：3

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