黄素单加氧酶3在药物代谢中的作用

被引：19

作者：

郝大程 ^{[1
,2
]}

杨凌 ^{[1
]}

机构：

[1] 中国科学院大连化学物理研究所药用资源开发研究组

[2] 中国科学院研究生院

来源：

中国药理学与毒理学杂志 | 2008年 / 05期

关键词：

黄素单加氧酶3; 代谢; 变异(遗传学); 多态性,单核苷酸;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

黄素单加氧酶(FMO,E.C.1.14.13.8)是重要的Ⅰ相代谢酶,由于与细胞色素P450(CYP450,E.C.1.14.14.1)具有相同的单加氧药物和异物代谢功能,其重要性被明显低估。本文在与CYP450进行对比的基础上,重点对FMO3的功能、变异、调控及应用等方面的最新进展进行了综述,并提出了进行FMO研究的未来策略。

引用

页码：391 / 395

页数：5

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