环加氧酶-2对帕金森病模型小鼠黑质多巴胺能神经元的影响

被引：3

作者：

李冬冬

张万琴

冯哲辉

机构：

[1] 大连医科大学生理教研室

[2] 香港大学医学院香港辽宁大连

[3] 辽宁大连

来源：

解剖科学进展 | 2002年 / 01期

关键词：

帕金森病; 1甲基4苯基1,2,3,6四氢吡啶; 环加氧酶; 酪氨酸羟化酶; 小鼠;

D O I：

10.16695/j.cnki.1006-2947.2002.01.010

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

1002 ;

摘要：

目的　观察COX 2对帕金森病小鼠黑质多巴胺能神经元的影响。方法　选用C5 7BL种系环加氧酶 2 (Cyclooxygenase 2 ,COX 2 )缺陷小鼠 ,腹腔注射 1 甲基 4 苯基 1,2 ,3,6 四氢吡啶 (MPTP)制备帕金森病小鼠模型 ,用免疫组织化学方法。结果　行为学及免疫组织化学观察显示 ,野生型帕金森病小鼠的死亡率明显高于COX 2缺陷杂合子帕金森病小鼠 (P <0 0 1) ;野生型帕金森病小鼠黑质致密部酪氨酸羟化酶 (Ty rosineHydroxylase ,TH)免疫反应阳性神经元数目较杂合子帕金森病小鼠明显减少 (P <0 0 1)。结论　COX 2很可能与帕金森病时黑质多巴胺能神经元的损伤有关

引用

页码：27 / 30

页数：4

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