TRPM8的研究进展

被引:13
作者
杜晶
张励才
机构
[1] 徐州医学院江苏省麻醉学重点实验室
关键词
TRPM8; 温度觉; 门控机制; 肿瘤;
D O I
暂无
中图分类号
R33 [人体生理学];
学科分类号
100123 [人体微生态学];
摘要
TRP(transient receptor potential)离子通道是一类广泛存在于细胞膜上的跨膜蛋白质,可以辨别酸甜苦辣等各种味觉和温暖、冷、热等各种温度觉。TRP通道亚型TRPM8最初作为一种前列腺特异性蛋白被克隆出来,并可在热敏反应中被冷刺激和薄荷醇激活。TRPM8可以感知温度觉和痛觉,并可缓解疼痛,具有重要的研究意义。该文拟就当前TR-PM8的生物物理学、门控机制和这类TRP通道的药理及病理生理机制等进行综述。
引用
收藏
页码:1135 / 1138
页数:4
相关论文
共 9 条
[1]
Mice Left Out in the Cold: Commentary on the Phenotype of TRPM8-Nulls[J] Richard L Daniels;David D McKemy Molecular Pain 2007,
[2]
TRPM8 Is Required for Cold Sensation in Mice[J] Ajay Dhaka;Amber N. Murray;Jayanti Mathur;Taryn J. Earley;Matt J. Petrus;Ardem Patapoutian Neuron 2007,
[3]
Analgesia Mediated by the TRPM8 Cold Receptor in Chronic Neuropathic Pain[J] Clare J. Proudfoot;Emer M. Garry;David F. Cottrell;Roberta Rosie;Heather Anderson;Darren C. Robertson;Susan M. Fleetwood-Walker;Rory Mitchell Current Biology 2006,
[4]
PERMEATION AND SELECTIVITY OF TRP CHANNELS[J] Grzegorz Owsianik;Karel Talavera;Thomas Voets;Bernd Nilius Annual Review of Physiology 2006,
[5]
Biophysical properties of menthol-activated cold receptor TRPM8 channels[J] Kwokyin Hui;Yibin Guo;Zhong-Ping Feng Biochemical and Biophysical Research Communications 2005,
[6]
Ca 2+ -dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8[J] Junji Abe;Hiroshi Hosokawa;Yosuke Sawada;Kiyoshi Matsumura;Shigeo Kobayashi Neuroscience Letters 2005,
[7]
Cold response of the bladder in guinea pig: Involvement of transient receptor potential channel; TRPM8[J] Yasuhiro Tsukimi;Kaori Mizuyachi;Tsugiko Yamasaki;Toshiro Niki;Fumihiko Hayashi Urology 2005,
[8]
The Super-Cooling Agent Icilin Reveals a Mechanism of Coincidence Detection by a Temperature-Sensitive TRP Channel[J] Huai-hu Chuang;Werner M. Neuhausser;David Julius Neuron 2004,
[9]
Identification of a cold receptor reveals a general role for TRP channels in thermosensation JuliusD;McKemy D D;NeuhausserW M; Nature 2002,