Th17/Treg失衡在消化道肿瘤中的研究进展

被引：4

作者：

郭美姿

陈晓琳

尹震宇

机构：

[1] 南京大学医学院附属鼓楼医院老年科

来源：

国际消化病杂志 | 2013年 / 33卷 / 05期

关键词：

T淋巴细胞; Th17; Treg; 消化道肿瘤;

D O I：

暂无

中图分类号：

R735 [消化系肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

辅助性T细胞17(Th17)与调节性T细胞(Treg)是CD4+T细胞的新亚群,CD4+T细胞在转化生长因子-β(TGF-β)和白细胞介素-6(IL-6)的共同诱导下分化为Th17细胞,分泌IL-17和IL-6,参与炎性反应和自身免疫性疾病,在TGF-β单独诱导下则分化成Treg,分泌TGF-β并表达Foxp3,参与免疫调节。正常情况下Th17细胞与Treg保持动态平衡,在机体的炎性反应、自身免疫性疾病、肿瘤和移植排斥等的发生发展中发挥重要作用,这种平衡的打破是很多炎性反应、自身免疫性疾病及肿瘤发病的一个关键因素。此文主要对Th17/Treg失衡与消化道肿瘤关系的研究进展作一综述。

引用

页码：341 / 344

页数：4

共 16 条

[1]

Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer [J].

Betts, Gareth ;

Jones, Emma ;

Junaid, Syed ;

El-Shanawany, Tariq ;

Scurr, Martin ;

Mizen, Paul ;

Kumar, Mayur ;

Jones, Sion ;

Rees, Brian ;

Williams, Geraint ;

Gallimore, Awen ;

Godkin, Andrew .

GUT, 2012, 61 (08) :1163-1171

[2]

Role of Foxp3-positive Tumor-infiltrating Lymphocytes in the Histologic Features and Clinical Outcomes of Hepatocellular Carcinoma [J].

Mathai, Alka Mary ;

Kapadia, Monesh J. ;

Alexander, Jacob ;

Kernochan, Lauren E. ;

Swanson, Paul E. ;

Yeh, Matthew M. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2012, 36 (07) :980-986

[3]

Imbalance of regulatory T cells to Th17 cells in IgA nephropathy [J].

Lin, Fu-Jun ;

Jiang, Geng-Ru ;

Shan, Jian-Ping ;

Zhu, Chun ;

Zou, Jun ;

Wu, Xiang-Ru .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2012, 72 (03) :221-229

[4]

The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications.[J].Chun Zeng;Xiaoyun Shi;Baojun Zhang;He Liu;Lianjun Zhang;Wenjun Ding;Yong Zhao.Journal of Molecular Medicine.2012, 2

[5]

Increased IL-17-producing CD4+ T cells in patients with esophageal cancer [J].

Chen, Deyu ;

Hu, Qin ;

Mao, Chaoming ;

Jiao, Zhijun ;

Wang, Shengjun ;

Yu, Lichao ;

Xu, Ying ;

Dai, Dongfang ;

Yin, Lijia ;

Xu, Huaxi .

CELLULAR IMMUNOLOGY, 2012, 272 (02) :166-174

[6]

Imbalance between Th17 and regulatory T-cells in systemic lupus erythematosus [J].

Kleczynska, Weronika ;

Jakiela, Bogdan ;

Plutecka, Hanna ;

Milewski, Mamert ;

Sanak, Marek ;

Musial, Jacek .

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, 2011, 49 (04) :646-653

[7]

Distribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer [J].

Maruyama, Takanori ;

Kono, Koji ;

Mizukami, Yoshiki ;

Kawaguchi, Yoshihiko ;

Mimura, Kousaku ;

Watanabe, Mitsuaki ;

Izawa, Shinichirou ;

Fujii, Hideki .

CANCER SCIENCE, 2010, 101 (09) :1947-1954

[8]

Involvement of T helper type 17 and regulatory T cell activity in tumour immunology of bladder carcinoma [J].

Chi, L. J. ;

Lu, H. T. ;

Li, G. L. ;

Wang, X. M. ;

Su, Y. ;

Xu, W. H. ;

Shen, B. Z. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2010, 161 (03) :480-489

[9]

Regulatory T Cells in Cancer.[J].Dimitrios Mougiakakos;Aniruddha Choudhury;Alvaro Lladser;Rolf Kiessling;C. Christian Johansson.Advances in Cancer Research.2010,

[10]

The Role of T-helper 17 (Th17) Cells in Patients with Medulloblastoma [J].

Zhou, P. ;

Sha, H. ;

Zhu, J. .

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2010, 38 (02) :611-619

← 1 2 →