内质网应激相关机制及其在炎症性肠病中的作用

被引：3

作者：

李凯

吴正祥

机构：

[1] 安徽医科大学附属省立医院消化内科

来源：

胃肠病学和肝病学杂志 | 2015年 / 24卷 / 03期

关键词：

肠内稳态; 炎症性肠病; 未折叠蛋白反应; 内质网应激;

D O I：

暂无

中图分类号：

R574 [肠疾病];

学科分类号：

1002 ; 100201 ;

摘要：

肠内稳态在维持胃肠正常功能方面发挥重要作用。肠内环境改变时,肠内稳态失衡,影响肠上皮细胞(intestinal epithelial cells,IECs)内质网腔内蛋白质折叠。当IECs内错误折叠蛋白过多或未折叠蛋白反应(unfolded protein response,UPR)功能受损时,引起内质网应激(endoplasmic reticulum stress,ERS),导致肠黏膜受损,介导炎症性肠病(inflammatory bowel disease,IBD)发生。固有免疫应答、自噬过程与ERS相互影响,共同促进IBD发展。本文就ERS相关机制及其在IBD发生中的作用作一概述。

引用

页码：253 / 256

页数：4

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