Niemann-Pick C1 Like 1研究新进展

被引:1
作者
朱雁飞
李幼生
黎介寿
机构
[1] 南京大学医学院临床学院(南京军区南京总医院)解放军普通外科研究所
关键词
NPC1L1; 肠道胆固醇吸收; 胆固醇转运;
D O I
10.16151/j.1007-810x.2009.06.007
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
摘要
Niemann-Pick C1 Like 1(NPC1L1)是肠道胆固醇吸收的关键蛋白,也是胆固醇吸收抑制剂依泽替米贝的分子作用靶点。NPC1L1的表达受一些核因子受体调控。敲除apoE-/-小鼠NPC1L1基因能显著抑制动脉粥样硬化的发生和发展,为动脉粥样硬化和冠状动脉性心脏病提供了新的治疗靶点。
引用
收藏
页码:373 / 376
页数:4
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