TGF-β信号通路及以其为靶点的肝病治疗药物研究进展

被引:17
作者
张森
孙妩弋
吴晶晶
胡姗姗
魏伟
机构
[1] 安徽医科大学临床药理研究所,抗炎免疫药物教育部重点实验室
基金
高等学校博士学科点专项科研基金;
关键词
转化生长因子β; TGF-β受体; 信号通路; 肝纤维化; 肝细胞癌; 靶向治疗药物;
D O I
暂无
中图分类号
R91 [药物基础科学];
学科分类号
100705 [微生物与生化药学];
摘要
转化生长因子β(transforming growth factorβ,TGF-β)是一类多功能的细胞因子,参与调控胚胎发育、创伤愈合、细胞增殖和分化等过程。此外,在多种肝病的发病机制中,TGF-β也发挥着调控作用。肝脏内多种细胞都能合成分泌TGF-β,并表达TGF-β的相关受体,通过不同的信号通路在肝病进程中起到至关重要的作用。该文将对TGF-β信号通路在肝病发生发展中的作用及以其为靶点的肝病治疗药物的研究进展作一综述。
引用
收藏
页码:1489 / 1493
页数:5
相关论文
共 14 条
[1]
Alcoholic liver disease[J] Radan Bruha;Karel Dvorak;Jaromir Petrty; World Journal of Hepatology 2012,
[2]
TGFβ信号转导通路及以其为靶点的肝纤维化治疗 [J].
刘浩 ;
魏伟 .
中国药理学通报, 2007, (05) :561-565
[3]
MAP kinase signalling cascades and transcriptional regulation[J] Shen-Hsi Yang;Andrew D. Sharrocks;Alan J. Whitmarsh Gene 2013,
[4]
p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice[J] Kengo Tomita;Toshiaki Teratani;Takahiro Suzuki;Tetsuya Oshikawa;Hirokazu Yokoyama;Katsuyoshi Shimamura;Kiyoshi Nishiyama;Norikazu Mataki;Rie Irie;Tohru Minamino;Yoshikiyo Okada;Chie Kurihara;Hirotoshi Ebinuma;Hidetsugu Saito;Ippei Shimizu;Yohko Yoshida;Ryota Hokari;Kazuo Sugiyama;Kazuo Hatsuse;Junji Yamamoto;Takanori Kanai;Soichiro Miura;Toshifumi Hibi Journal of Hepatology 2012,
[5]
Post-translational regulation of TGF-β receptor and Smad signaling[J] Pinglong Xu;Jianming Liu;Rik Derynck FEBS Letters 2012,
[6]
Dynamics of TGF-β/Smad signaling[J] Zhike Zi;Douglas A. Chapnick;Xuedong Liu FEBS Letters 2012,
[7]
Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver[J] Lisa Nicole Gerjevic;Na Liu;Sizhao Lu;Duygu Dee Harrison-Findik;Angela Dolganiuc International Journal of Hepatology 2011,
[8]
TGF-β in progression of liver disease[J] Steven Dooley;Peter Dijke Cell and Tissue Research 2012,
[9]
Activin A in Nonalcoholic Fatty Liver Disease[J] Vitamins and Hormones 2011,
[10]
Smad3 Signaling Critically Regulates Fibroblast Phenotype and Function in Healing Myocardial Infarction[J] Marcin Dobaczewski;Marcin Bujak;Na Li;Carlos Gonzalez-Quesada;Leonardo H. Mendoza;Xiao-Fan Wang;Nikolaos G. Frangogiannis Circulation Research 2010,