支气管哮喘气道高反应性机制的研究进展

被引：19

作者：

张景鸿

李超乾

机构：

[1] 广西医科大学第一附属医院呼吸内科

来源：

中国呼吸与危重监护杂志 | 2011年 / 10卷 / 03期

关键词：

气道高反应性; 气道炎症; 支气管哮喘; 哮喘; AHR;

D O I：

暂无

中图分类号：

R562.25 [];

学科分类号：

1002 ; 100201 ;

摘要：

气道高反应性(AHR)又称支气管高反应性,是指气道本身对各种特异性或非特异性刺激的反应性异常增高,主要表现为气道平滑肌的过早或过强的收缩反应、支气管痉挛和黏液腺体分泌的亢进。AHR是支气管哮喘的重要特征之一,是一种反映哮喘患者气道功能异常状态的关键指标,并

引用

页码：304 / 307

页数：4

共 6 条

[1] Eosinophil-derived IFN-γ induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes [J].

Kanda, Akira ;

Driss, Virginie ;

Hornez, Nicolas ;

Abdallah, Marwan ;

Roumier, Thomas ;

Abboud, Georges ;

Legrand, Fanny ;

Staumont-Salle, Delphine ;

Queant, Severine ;

Bertout, Julie ;

Fleury, Sebastien ;

Remy, Patrick ;

Papin, Jean-Paul ;

Julia, Valerie ;

Capron, Monique ;

Dombrowicz, David .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (03) :573-U269

[2] All roads lead to Rome: pathways of NKT cells promoting asthma [J].

Tan Jinquan ;

Wang Li ;

He Yuling ;

Chen Lang .

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 2006, 54 (05) :335-340

[3]

THE EOSINOPHIL[J] . Marc E. Rothenberg,Simon P. Hogan.Annual Review of Immunology . 2006

[4] Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine [J].

Barczyk, A ;

Pierzchala, W ;

Sozañska, E .

RESPIRATORY MEDICINE, 2003, 97 (06) :726-733

[5]

Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids[J] . Meghan Cundall,Yongchang Sun,Christina Miranda,John B. Trudeau,Stephen Barnes,Sally E. Wenzel.The Journal of Allergy and Clinical Immunology . 2003 (6)

[6] Allergen-induced impairment of bronchoprotective nitric oxide synthesis in asthma [J].

Ricciardolo, FLM ;

Timmers, MC ;

Geppetti, P ;

van Schadewijk, A ;

Brahim, JJ ;

Sont, JK ;

de Gouw, HWFM ;

Hiemstra, PS ;

van Krieken, JHJM ;

Sterk, PJ .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (02) :198-204

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