作用于血液系统的蛇毒蛋白酶的研究进展

被引:1
作者
李红枝
刘玉超
唐松山
机构
[1] 广东药学院基础学院广东省重点生物活性实验室
关键词
蛇毒; 血液系统; 丝氨酸蛋白酶; 金属蛋白酶; 磷脂酶A2; L-氨基酸氧化酶; 5'-核苷酸酶;
D O I
暂无
中图分类号
R284.1 [化学分析与鉴定];
学科分类号
1008 ;
摘要
蛇毒是蛇毒腺分泌的天然毒液,含有多种蛋白质、多肽、酶类和其它小分子物质,它们参与蛇的捕食消化和防御功能。蛇毒中含有许多种影响血液系统功能的蛋白质或酶,因其显著的生物功能和药用活性,受到广泛关注。本文就对蛇毒中影响血液系统的丝氨酸蛋白酶、金属蛋白酶、磷脂酶A2、L-氨基酸氧化酶和5'-核苷酸酶等蛋白酶的最新研究进展进行了综述。
引用
收藏
页码:917 / 920
页数:4
相关论文
共 29 条
[1]  
Competitive interac-tions of collagen and a jararhagin-derived disintegrin peptide withthe integrina2-Ⅰdomain. Lambert L J,Bobkov A A,Smith J W,et al. Journal of Biological Chemistry . 2008
[2]   Biochemical and functional properties of a thrombin-like enzyme isolated from Bothrops pauloensis snake venom [J].
Costa, Fabio L. S. ;
Rodrigues, Renata S. ;
Izidoro, Luiz F. M. ;
Menaldo, Danilo L. ;
Hamaguchi, Amelia ;
Homsi-Brandeburgo, Maria I. ;
Fuly, Andre L. ;
Soares, Sandro G. ;
Selistre-de-Araujo, Heloisa S. ;
Barraviera, Benedito ;
Soares, Andreimar M. ;
Rodrigues, Veridiana M. .
TOXICON, 2009, 54 (06) :725-735
[3]   Biochemical and Hemostatic Mechanism of A Novel Thrombin-Like Enzyme [J].
Tang, Song-Shan ;
Zhang, Juan-Hui ;
Tang, Bai-Shan ;
Tang, Zhi-Hua ;
Li, Hong-Zhi ;
Yuan, Hao-Jia ;
Chui, Shu-Lian ;
Zhao, Er-Yao .
THROMBOSIS RESEARCH, 2009, 124 (05) :631-639
[4]  
The novel metalloproteinase atroxlysin-I from Peruvian Bothrops atrox (Jergón) snake venom acts both on blood vessel ECM and platelets[J] . Eladio F. Sanchez,Francisco S. Schneider,Armando Yarleque,Marcia H. Borges,Michael Richardson,Suely G. Figueiredo,Karla S. Evangelista,Johannes A. Eble. &nbspArchives of Biochemistry and Biophysics . 2010 (1)
[5]  
Bhalternin: Functional and structural characterization of a new thrombin-like enzyme from Bothrops alternatus snake venom[J] . Júnia de O. Costa,Kelly C. Fonseca,Carla C. Neves Mamede,Marcelo E. Beletti,Norival A. Santos-Filho,Andreimar M. Soares,Eliane C. Arantes,Silvia N.S. Hirayama,Heloísa S. Selistre-de-Araújo,Fernando Fonseca,Flávio Henrique-Silva,Nilson Penha-Silva,Fábio de Oliveira. &nbspToxicon . 2010 (7)
[6]  
Biochemical and hemostaticmechanism of a novel thrombin-like enzyme. Tang S S,Zhang J H,Tang B S,et al. Thrombosis Research . 2009
[7]   A high-throughput venom-gland transcriptome for the Eastern Diamondback Rattlesnake (Crotalus adamanteus) and evidence for pervasive positive selection across toxin classes [J].
Rokyta, Darin R. ;
Wray, Kenneth P. ;
Lemmon, Alan R. ;
Lemmon, Emily Moriarty ;
Caudle, S. Brian .
TOXICON, 2011, 57 (05) :657-671
[8]   长白山白眉蝮蛇毒类凝血酶的分离纯化 [J].
牟萍 ;
尹家荣 ;
侯瑞鹏 ;
于鸿儒 .
锦州医学院学报, 2005, (05) :43-46
[9]   白唇竹叶青蛇毒5′-核苷酸酶的分离纯化及性质 [J].
陈夏 ;
余晓东 ;
邓敏 ;
李卉 ;
林亦心 ;
和七一 ;
柳建平 .
动物学研究, 2008, (04) :399-404
[10]  
Purification and characterization of a new L-amino acid oxidase from Daboia russellii siamensis venom. Zhang SR,Jin Y,Wu JB,Jia YH, et al. Toxicon . 2009