夏天无总碱中抗胆碱酯酶活性成分的研究

被引：23

作者：

徐丽华

顾振纶

蒋小岗

盛瑞

王晓庆

谢梅林

机构：

[1] 苏州大学医学院,苏州中药研究所,苏州中药研究所,苏州中药研究所,苏州中药研究所,苏州中药研究所江苏苏州

来源：

药学学报 | 2002年 / 11期

关键词：

夏天无; 四氢掌叶防己碱; 原阿片碱; 比枯枯灵碱; l斯库来碱; 去氢紫堇碱; 抗胆碱酯酶;

D O I：

10.16438/j.0513-4870.2002.11.016

中图分类号：

R284 [中药化学];

学科分类号：

1008 ;

摘要：

AIM To study on the anticholinesterase active constituents of the rhizoma ofCorydalis decumbens. METHODS Various chromatography techniques were used to isolate and purify the chemical constituents. Their structures were elucidated by UV, IR, MS, 1HNMR and ~ 13CNMR spectral analyses. Their anticholinesterase activity was measured with Ellman method. RESULTS Five compounds were identified as tetrahydropalmatine （I）, protopine （II）, bicuculine （III）, sculerine （IV） and dehydrocorydaline （V）. Compounds II and III possessed the action of anticholinesterase activity. CONCLUSION Protopine （II） is the one of main anticholinesterase active constituents of the rhizoma ofCorydalis decumbens.

引用

页码：902 / 903

页数：2