女性骨代谢转换生化指标和骨密度随龄变化及其相互关系

被引：20

作者：

单鹏飞

伍贤平

廖二元

张红

罗湘杭

曹行之

谢辉

刘石平

机构：

[1] 中南大学湘雅二医院代谢内分泌研究所

[2] 中南大学湘雅二医院代谢内分泌研究所长沙市

[3] 长沙市

来源：

中华老年医学杂志 | 2005年 / 06期

关键词：

骨钙素; I型胶原N末端肽; 脱氧吡啶啉; 骨密度;

D O I：

暂无

中图分类号：

R446.1 [生物化学检验、临床检验];

学科分类号：

100208 ;

摘要：

目的观察女性血清骨钙素、I型胶原N末端肽(NTx)、尿脱氧吡啶啉(DPD)和骨密度(BMD)随年龄变化的规律,探讨骨转换生化指标和BMD的关系。方法采用酶联免疫吸附法测定895例女性血清骨钙素、NTx和尿DPD;用Hitachi7170A全自动生化分析仪测定尿肌酐;采用双能X线骨密度仪测定1～4腰椎后前位(L14)和左侧髋部股骨颈BMD。结果血清骨钙素、NTx和尿DPD与年龄相关,用三次回归方程拟合的决定系数R2为0.060～0.243(P=0.000)。骨钙素、NTx和尿DPD在30～39岁降低至最低水平,40～59岁显著升高,随后维持在较高水平。骨钙素、NTx和尿DPD3个指标呈显著性相关(r=0.118～0.346,P=0.000)。骨钙素、NTx和尿DPD与腰椎和股骨颈BMD呈负相关(r=-0.120～-0.347,P=0.001～0.000),高骨转换型绝经后妇女腰椎和股骨颈原发性骨质疏松症的患病风险为1.6～3.6。用三次回归方程或复合模型拟合骨钙素、NTx、尿DPD伴随L14和股骨颈BMD变化的决定系数为0.008～0.275(P=0.007～0.000)。结论女性年龄依赖性骨转换生化指标和BMD呈负相关;绝经后妇女高骨转换状态是原发性骨质疏松症患病的危险因素。

引用

页码：431 / 434

页数：4

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