骨关节炎发病机理的研究进展

被引:29
作者
张新玉
魏丽
机构
[1] 上海浦东新区公利医院风湿免疫科
关键词
骨关节炎; 炎性因子; 凋亡;
D O I
暂无
中图分类号
R684.3 [关节炎];
学科分类号
100220 [骨科学];
摘要
<正>骨关节炎(osteoarthritis,OA)为一种退行性骨关节病,系由于年龄增长、肥胖、劳损、创伤、关节畸形等因素引起的关节软骨退化、关节边缘和软骨下骨反应性增生。现阶段OA的发病机制仍尚未阐明,目前普遍认为是力学和生物学因素的共同作用,其结果导致软骨细胞、细胞外基质及软骨下骨三者降解和合成失衡[1],这种失衡与炎性因子介导、细胞凋亡和压力机
引用
收藏
页码:666 / 668
页数:3
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