角质形成细胞在银屑病中作用的研究进展

被引：18

作者：

黄海勇 ^{[1
]}

黄功华 ^{[2
]}

刘新光 ^{[1
]}

机构：

[1] 广东省医学分子诊断重点实验室广东医科大学衰老研究所广东医科大学生物化学与分子生物学研究所

[2] 上海市免疫学研究所,上海交通大学医学院

来源：

中国免疫学杂志 | 2020年 / 36卷 / 12期

关键词：

银屑病; 角质形成细胞; 免疫细胞; 皮肤屏障; 增殖;

D O I：

暂无

中图分类号：

R758.63 [牛皮癣（银屑病）];

学科分类号：

100227 [皮肤病学];

摘要：

银屑病是慢性复发性皮肤疾病,其发生与免疫功能失调、环境因素、信号转导通路紊乱及银屑病易感基因相关。既往研究表明角质形成细胞(KC)在银屑病的发生发展中发挥重要作用。银屑病中KC如何影响炎症细胞的募集、活化,及炎症因子如何导致炎症级联放大尚不明确。KC作为银屑病治疗的靶标,具有广泛的应用前景。本文从银屑病中KC的屏障功能、增殖分化及角质形成细胞与免疫细胞的相互作用作综述。

引用

页码：1527 / 1530

页数：4

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