急性冠状动脉综合征患者外周血中脂联素水平与IL-10及TIMP-1的相关性

被引：4

作者：

程敏

曾秋棠

机构：

[1] 华中科技大学协和医院心内科华中科技大学同济医学院心血管研究所

来源：

临床心血管病杂志 | 2006年 / 11期

关键词：

脂联素; 急性冠状动脉综合征; 白细胞介素-10; 基质金属蛋白酶组织抑制因子-1;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的:探讨急性冠状动脉综合征(ACS)患者外周血中脂联素水平与白细胞介素(IL)-10和基质金属蛋白酶组织抑制因子(TIMP)-1的相关性。方法:设立ACS组,50例;稳定型心绞痛组(SA组),13例;正常对照组,22例。用双抗体夹心酶联免疫吸附法检测各组外周血中脂联素、IL-10和TIMP-1的浓度。结果:ACS组与正常对照组相比,外周血清中脂联素、IL-10和TIMP-1的浓度均显著降低(均P<0.01);SA组与正常对照组相比,脂联素、IL-10及TIMP-1的浓度均差异无统计学意义(均P>0.05)。ACS组与SA组相比,脂联素和IL-10的浓度显著降低(P<0.01和P<0.05),TIMP-1的浓度差异无统计学意义(P>0.05)。在各指标之间的相关性分析中:脂联素与IL-10和TIMP-1之间的相关性均有统计学意义(r=0.691,P<0.01和r=0.660,P<0.01)。结论:ACS患者血清中脂联素和IL-10的分泌减少,导致TIMP-1的分泌也减少,可能是ACS发生的重要因素。

引用

页码：645 / 647

页数：3

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