体外循环中抗肿瘤坏死因子抗体的肺保护作用

被引:3
作者
于洋
蒋树林
刘艳萍
祁家驹
夏求明
机构
[1] 哈尔滨医科大学附属第二医院心外科
关键词
心脏瓣膜假体植入; 肿瘤坏死因子; 抗体; 心肺转流术; 肺损伤; 肺保护;
D O I
暂无
中图分类号
R654.1 [体外循环及复苏术];
学科分类号
1002 ; 100210 ;
摘要
目的 探讨抗肿瘤坏死因子抗体 (TNF αAb)对体外循环 (CPB)肺损伤的保护作用。方法 选择CPB瓣膜置换病人 2 0例 ,随机分为对照组和用药组各 10例。用药组于CPB前和主动脉开放后即刻经气管插管注入TNF αAb。测定两组围CPB期肺动态顺应性 ,左、右心房血中性粒细胞计数、肿瘤坏死因子 (TNF α)含量等指标。结果 用药组CPB后各时点肺动态顺应性显著高于对照组 ;TNF αAb明显抑制肺源性TNF(COB) α的释放及中性粒细胞在肺内的聚集。结论 预防性应用TNF αAb对体外循环肺损伤有明显的保护作用。
引用
收藏
页码:35 / 37
页数:3
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