个性化3D打印多孔钛合金加强块重建重度髋臼骨缺损的生物相容性和生物力学研究

被引：22

作者：

付君

倪明

陈继营

邓涛

管海涛

贾承奇

徐驰

柴伟

郝立波

机构：

[1] 解放军总医院骨科

来源：

中国矫形外科杂志 | 2018年 / 26卷 / 10期

基金：

国家高技术研究发展计划(863计划);

关键词：

髋臼骨缺损; 钛合金; 生物力学; 生物相容性;

D O I：

暂无

中图分类号：

R318.08 [生物材料学];

学科分类号：

100103 [病原生物学];

摘要：

[目的]评价巴马小型猪髋臼骨缺损模型个性化3D打印多孔钛合金加强块多孔内骨长入情况和生物力学性能。[方法]在巴马小型猪建立髋臼缺损模型,制备个性化3D打印多孔钛合金加强块置于缺损处。扫描电子显微镜测量多孔钛合金加强块多孔涂层内部结构参数(孔隙率、孔径和梁径),CT扫描三维重建测量个性化加强块置入术后的匹配率;力学试验机测量加强块的刚度、抗压强度和弹性模量以及加强块置入术后的生物力学;Micro-CT检查评价加强块多孔涂层内的骨长入和骨整合。[结果]钛合金加强块内部结构参数,总孔隙率为(55.48±0.61)%,孔径(319.23±25.05)μm,梁径(240.10±23.50)μm;力学性能参数:刚度为(21 464.60±1 091.69)N/mm,抗压强度为(231.10±11.77)MPa,弹性模量为(5.35±0.23)GPa。加强块置入术后的匹配度为:(91.40±2.83)%。Micro-CT扫描结果显示个性化3D打印多孔钛合金加强块的多孔涂层内有骨小梁长入;个性化3D打印多孔钛合金加强块置入术后即刻和12周最大抗剪切强度载荷值分别为(929.46±295.99)N和(1 521.93±98.38)N(P=0.030)。[结论]本研究中设计的个性化3D打印多孔钛合金加强块具有良好的骨组织生物相容性和生物力学性能。

引用

页码：945 / 950

页数：6

共 15 条

[1]

Numerical optimization of open-porous bone scaffold structures to match the elastic properties of human cortical bone.[J].Jan Wieding;Andreas Wolf;Rainer Bader.Journal of the Mechanical Behavior of Biomedical Materials.2014,

[2]

Effects of thermomechanical process on the microstructure and mechanical properties of a fully martensitic titanium-based biomedical alloy.[J].W. Elmay;F. Prima;T. Gloriant;B. Bolle;Y. Zhong;E. Patoor;P. Laheurte.Journal of the Mechanical Behavior of Biomedical Materials.2013,

[3]

Development of new metallic alloys for biomedical applications [J].

Niinomi, Mitsuo ;

Nakai, Masaaki ;

Hieda, Junko .

ACTA BIOMATERIALIA, 2012, 8 (11) :3888-3903

[4]

Development and mechanical characterization of porous titanium bone substitutes.[J].A. Barbas;A.-S. Bonnet;P. Lipinski;R. Pesci;G. Dubois.Journal of the Mechanical Behavior of Biomedical Materials.2012,

[5]

A design for the additive manufacture of functionally graded porous structures with tailored mechanical properties for biomedical applications.[J].Jayanthi Parthasarathy;Binil Starly;Shivakumar Raman.Journal of Manufacturing Processes.2011, 2

[6]

Indirect rapid prototyping of biphasic calcium phosphate scaffolds as bone substitutes: influence of phase composition, macroporosity and pore geometry on mechanical properties [J].

Schumacher, M. ;

Deisinger, U. ;

Detsch, R. ;

Ziegler, G. .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2010, 21 (12) :3119-3127

[7]

Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM).[J].Jayanthi Parthasarathy;Binil Starly;Shivakumar Raman;Andy Christensen.Journal of the Mechanical Behavior of Biomedical Materials.2009, 3

[8]

A New Era in Porous Metals: Applications in Orthopaedics [J].

Levine, Brett .

ADVANCED ENGINEERING MATERIALS, 2008, 10 (09) :788-792

[9]

Ti based biomaterials; the ultimate choice for orthopaedic implants – A review.[J].M. Geetha;A.K. Singh;R. Asokamani;A.K. Gogia.Progress in Materials Science.2008, 3

[10]

Hybrid bone implants: Self-assembly of peptide amphiphile nanofibers within porous titanium.[J].Timothy D. Sargeant;Mustafa O. Guler;Scott M. Oppenheimer;Alvaro Mata;Robert L. Satcher;David C. Dunand;Samuel I. Stupp.Biomaterials.2007, 2

← 1 2 →