扩张型心肌病免疫病理学发病机制研究进展

被引：29

作者：

张晓伟

蔡文锋

胡卓伟

机构：

[1] 中国医学科学院北京协和医学院药物研究所

来源：

心血管病学进展 | 2009年 / 30卷 / 05期

关键词：

扩张型心肌病; 炎症; 免疫反应; Toll样受体; 损伤相关分子模式分子;

D O I：

暂无

中图分类号：

R542.2 [心肌疾病];

学科分类号：

100201 [内科学];

摘要：

扩张型心肌病是由多种致病因素引发的严重危害公众健康的心脏疾病,患者常因心脏组织损伤和异常重构而导致慢性心力衰竭。最近的研究提示:许多致病原如病毒、药物等可以引起心脏局部炎症反应和组织损伤,而受损组织释放损伤相关分子模式分子,通过模式识别受体如Toll样受体的介导参与扩张型心肌病的发病。发现并探讨相关损伤相关分子模式分子造成心脏损伤和心室异常重构的免疫病理学机制可以为探索扩张型心肌病新的诊疗策略提供理论依据。

引用

页码：814 / 817

页数：4

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