多药耐药蛋白P-糖蛋白及其抑制剂的研究进展

被引:4
作者
曾玮
雷正明
机构
[1] 四川泸州医学院附属医院肝胆外科
关键词
P-糖蛋白; 抑制剂; 多药耐药;
D O I
暂无
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
胰腺癌的化疗效果不理想主要原因与肿瘤细胞的多药耐药有关。胰腺癌细胞多药耐药产生的机制目前并未阐明,随着对多药耐药认识的不断深入,新的逆转剂已经产生。本文通过近5年文献资料的回顾复习,对胰腺癌耐药机制及其抑制剂的研究进展作一综述。
引用
收藏
页码:114 / 116
页数:3
相关论文
共 11 条
[1]   Mechanisms and strategies to overcome multiple drug resistance in cancer [J].
Ozben, Tomris .
FEBS LETTERS, 2006, 580 (12) :2903-2909
[2]   Do drug substrates enter the common drug-binding pocket of P-glycoprotein through "gates"? [J].
Loo, TW ;
Clarke, DM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 329 (02) :419-422
[3]   Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux [J].
Loo, TW ;
Clarke, DM .
JOURNAL OF MEMBRANE BIOLOGY, 2005, 206 (03) :173-185
[4]  
P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement[J] . Manthena V.S Varma,Yasvanth Ashokraj,Chinmoy S Dey,Ramesh Panchagnula.Pharmacological Research . 2003 (4)
[5]   Considerations in the design and development of transport inhibitors as adjuncts to drug therapy [J].
Dantzig, AH ;
de Alwis, DP ;
Burgess, M .
ADVANCED DRUG DELIVERY REVIEWS, 2003, 55 (01) :133-150
[6]   The mechanism of action of multidrug-resistance-linked P-glycoprotein [J].
Sauna, ZE ;
Smith, MM ;
Müller, M ;
Kerr, KM ;
Ambudkar, SV .
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 2001, 33 (06) :481-491
[7]  
BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER1[J] . Suresh V. Ambudkar,Saibal Dey,Christine A. Hrycyna,Muralidhara Ramachandra,Ira Pastan,Michael M. Gottesman.Annual Review of Pharmacology and Toxicology . 1999
[8]  
The P-Glycoprotein Efflux Pump: How Does it Transport Drugs?[J] . F.J. Sharom.The Journal of Membrane Biology . 1997 (3)
[9]   How does P-glycoprotein recognize its substrates? [J].
Ueda, K ;
Taguchi, Y ;
Morishima, M .
SEMINARS IN CANCER BIOLOGY, 1997, 8 (03) :151-159
[10]  
Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption[J] . Janice Hunter,Barry H. Hirst.Advanced Drug Delivery Reviews . 1997 (2)