基质金属蛋白酶-2的表达及微血管密度与宫颈癌侵袭性的相关性

被引：6

作者：

詹平

毛熙光

董述全

张宇骄

伍宗惠

毛惠

机构：

[1] 泸州医学院附属医院妇产科

来源：

现代肿瘤医学 | 2008年 / 02期

关键词：

宫颈癌; 基质金属蛋白酶-2; 微血管密度; 肿瘤转移; 免疫组织化学;

D O I：

暂无

中图分类号：

R737.33 [子宫肿瘤];

学科分类号：

摘要：

目的:研究宫颈癌组织中基质金属蛋白酶-2(MMP-2)的表达及微血管密度(MVD)与宫颈癌侵袭转移的相关关系。方法:采用免疫组化SP法,分别测定12例正常宫颈组织、14例宫颈原位癌、56例宫颈浸润癌组织中MMP-2的表达及MVD值。结果:宫颈癌中,MMP-2主要表达于细胞浆和/或细胞膜,CD34主要表达于间质血管内皮细胞。宫颈浸润癌MMP-2表达明显高于宫颈原位癌和正常宫颈组织,宫颈浸润癌组织MVD与宫颈原位癌和正常宫颈组织比较,有显著统计学差异(P=0.000)。MMP-2及MVD与临床分期、组织学类型、细胞分化程度及淋巴结转移均有一定关系。结论:MMP-2在宫颈癌的浸润和转移中发挥了重要作用,MVD值增高与肿瘤进展有密切关系,可作为观察宫颈癌进展的重要指标。

引用

页码：262 / 265

页数：4

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