多囊卵巢综合征患者胰岛素抵抗和高胰岛素血症的诊治

被引：83

作者：

曹云霞

唐静文

机构：

[1] 安徽医科大学第一附属医院生殖医学中心

来源：

中国实用妇科与产科杂志 | 2013年 / 29卷 / 11期

关键词：

胰岛素抵抗; 多囊卵巢综合征; 高雄激素血症; 胰岛素增敏剂;

D O I：

暂无

中图分类号：

R711.75 [卵巢疾病];

学科分类号：

100211 [妇产科学];

摘要：

胰岛素抵抗(IR)是多囊卵巢综合征(PCOS)的重要病理生理改变。IR及高胰岛素血症是PCOS患者代谢异常的基本特征,也是PCOS患者内分泌代谢紊乱的主要特征之一。肥胖型PCOS患者高胰岛素血症发生率高达75%,非肥胖型PCOS患者约为30%。流行病学调查显示PCOS患者发生2型糖尿病、高血压、冠心病等疾病的风险明显增加,胰岛素抵抗可能在PCOS的发生中起着重要作用。生活方式改变和胰岛素增敏剂是治疗的有效方法。

引用

页码：864 / 866

页数：3

共 11 条

[1]

Interventions for the metabolic dysfunction in polycystic ovary syndrome [J].

Bozdag, Gurkan ;

Yildiz, Bulent O. .

STEROIDS, 2013, 78 (08) :777-781

[2]

Ontogeny of polycystic ovary syndrome and insulin resistance in utero and early childhood [J].

Abbott, David H. ;

Bacha, Fida .

FERTILITY AND STERILITY, 2013, 100 (01) :2-11

[3]

Prevalence of polycystic ovary syndrome in women in China: a large community-based study [J].

Li, Rong ;

Zhang, Qiufang ;

Yang, Dongzi ;

Li, Shangwei ;

Lu, Shulan ;

Wu, Xiaoke ;

Wei, Zhaolian ;

Song, Xueru ;

Wang, Xiuxia ;

Fu, Shuxin ;

Lin, Jinfang ;

Zhu, Yimin ;

Jiang, Yong ;

Feng, Huai L. ;

Qiao, Jie .

HUMAN REPRODUCTION, 2013, 28 (09) :2562-2569

[4]

Effects of Thiazolidinediones on Polycystic Ovary Syndrome: a Meta-analysis of Randomized Placebo-Controlled Trials [J].

Du, Qiang ;

Yang, Sheng ;

Wang, Yan-Jun ;

Wu, Bo ;

Zhao, Yue-Yang ;

Fan, Bin .

ADVANCES IN THERAPY, 2012, 29 (09) :763-774

[5]

Rosiglitazone treatment alleviates inflammation and improves liver function in overweight women with polycystic ovary syndrome: a randomized placebo-controlled study [J].

Rautio, Katrina ;

Tapanainen, Juha S. ;

Ruokonen, Aimo ;

Morin-Papunen, Laure C. .

FERTILITY AND STERILITY, 2007, 87 (01) :202-206

[6]

Early effects of metformin in women with polycystic ovary syndrome: A prospective randomized, double-blind, placebo-controlled trial [J].

Eisenhardt, S ;

Schwarzmann, N ;

Henschel, V ;

Germeyer, A ;

von Wolff, M ;

Hamann, A ;

Strowitzki, T .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (03) :946-952

[7]

Endocrine–metabolic effects of the treatment with pioglitazonein obese patients with polycystic ovary syndrome.[J].Heraldo M. Garmes;Marcos A. Tambascia;Denise E. Zantut-Wittmann.Gynecological Endocrinology.2005, 6

[8]

The prevalence and features of the polycystic ovary syndrome in an unselected population [J].