Survivin与肿瘤的关系

被引：9

作者：

杜冠辉 ^{[1
]}

谭金凤 ^{[2
]}

吴淑金 ^{[1
]}

李强 ^{[1
]}

机构：

[1] 广东省医学情报研究所《实用医学杂志》编辑部

[2] 中山大学附属第一医院妇产科

来源：

医学综述 | 2008年 / 05期

关键词：

Survivin; 肿瘤; 细胞凋亡; 细胞周期; 抗肿瘤药;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学]; R730.5 [肿瘤治疗学];

学科分类号：

100214 ;

摘要：

Survivin是凋亡抑制蛋白家族成员之一,在细胞凋亡和分化中扮演着重要角色,对细胞周期起调控作用。人类胚胎和大多数肿瘤细胞中均有survivin的表达,但在正常分化成熟的细胞中却极少。许多抗肿瘤药物通过诱导细胞凋亡而发挥抗肿瘤作用,但某些肿瘤表现出对它们的抗药性。导致肿瘤抗药性的一个最重要的因素就是survivin的表达。有关细胞凋亡途径和survivin表达方面的研究可提供发现和发展新型抗肿瘤药的新途径。

引用

页码：658 / 660

页数：3

共 7 条

[1]

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[2]

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[6]

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[7]

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