瘦素与急性心肌梗死溶栓后ST段变化的关系探讨

被引：6

作者：

徐彤彤

戴玲

机构：

[1] 广西桂林医学院附属医院心血管内科

来源：

广西医科大学学报 | 2007年 / 03期

关键词：

急性心肌梗死; 瘦素; 心电图ST段;

D O I：

10.16190/j.cnki.45-1211/r.2007.03.073

中图分类号：

R542.22 [];

学科分类号：

1002 ; 100201 ;

摘要：

目的:研究急性心肌梗死(AMI)患者溶栓再灌注治疗前后瘦素的变化与心电图ST段回落的关系,为AMI提供简便有效的预后评估指标。方法:AMI组30例,为AMI患者,溶栓前后(0、24h)测定其血清瘦素,同时定时检查12导联(下壁AMI18导联)心电图,并进行ST段回落分析,计算回落百分比。患者划分为两组,A组为ST回落≥50%的患者,B组为ST回落<50%的患者。对这些患者的血清瘦素变化和ST段回落之关系分别进行探讨。对照组20例,为心电图正常值非亲缘关系者,与AMI组年龄、体重指数(BMI)和腰臀比(WHR)相匹配,测空腹血清瘦素,提供瘦素的基础水平。结果:①与对照组比较,AMI组血清瘦素水平升高[(14.72±3.01)μg/Lvs(3.24±1.12)μg/L](P<0.05);②AMI患者溶栓前血清瘦素水平高低与溶栓后24hST段回落相关,A组患者血清瘦素水平为(12.70±3.67)μg/L,显著低于B组患者的(17.45±1.05)μg/L(P<0.01);③AMI患者溶栓24h后,A组与B组相比,瘦素下降百分比与24hST段回落相关(P<0.01)。结论:瘦素参与了AMI心肌损伤过程,高瘦素血症预示溶栓疗效差,AMI治疗中瘦素降低提示预后较好。

引用

页码：403 / 405

页数：3

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