低氧张力下骨髓间充质干细胞增殖与成骨分化特点及研究进展

被引：9

作者：

高悠水

朱珍宏

胡斌

于晓巍

王信富

张长青

机构：

[1] 上海交通大学附属第六人民医院骨科

来源：

国际骨科学杂志 | 2011年 / 32卷 / 05期

关键词：

低氧; 骨髓间充质干细胞; 增殖; 分化; p53; 低氧诱导因子-1;

D O I：

暂无

中图分类号：

R683 [骨折、骨的损伤];

学科分类号：

100220 [骨科学];

摘要：

骨髓间充质干细胞(BMSC)生存的微环境处于低氧状态,当病理性因素存在时局部骨组织内BMSC将面临更加窘迫的低氧应激。近年研究发现,低氧诱导因子(HIF)-1是调控低氧张力下BMSC增殖、维持其干细胞特性的重要转录调控因子。低氧对BMSC增殖的影响与其张力大小、持续时间有关,且在不同细胞类型之间可能也有差异。p53调控BMSC低氧张力下的分化与HIF-1密切相关。通过分子生物学方法调控BMSC增殖和分化方式,对于促进骨折愈合、治疗骨折并发症具有重要意义。

引用

页码：318 / 320

页数：3

共 19 条

[1]

Concise Review: Insights from Normal Bone Remodeling and Stem Cell-Based Therapies for Bone Repair [J].

Khosla, Sundeep ;

Westendorf, Jennifer J. ;

Moedder, Ulrike I. .

STEM CELLS, 2010, 28 (12) :2124-2128

[2]

Mesenchymal Stem Cells as Therapeutics.[J].Biju Parekkadan;Jack M. Milwid.Annual Review of Biomedical Engineering.2010, 1

[3]

p53 and stem cells: new developments and new concerns [J].

Zhao, Tongbiao ;

Xu, Yang .

TRENDS IN CELL BIOLOGY, 2010, 20 (03) :170-175

[4]

Does mobilisation and transmigration of mesenchymal stem cells occur after trauma? [J].

Giannoudis, P. V. ;

Goff, T. ;

Roshdy, T. ;

Jones, E. ;

McGonagle, D. .

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 2010, 41 (11) :1099-1102

[5]

Hypoxia Promotes Efficient Differentiation of Human Embryonic Stem Cells to Functional Endothelium [J].

Prado-Lopez, Sonia ;

Conesa, Ana ;

Arminan, Ana ;

Martinez-Losa, Magdalena ;

Escobedo-Lucea, Carmen ;

Gandia, Carolina ;

Tarazona, Sonia ;

Melguizo, Dario ;

Blesa, David ;

Montaner, David ;

Sanz-Gonzalez, Silvia ;

Sepulveda, Pilar ;

Goetz, Stefan ;

Enrique O'Connor, Jose ;

Moreno, Ruben ;

Dopazo, Joaquin ;

Burks, Deborah J. ;

Stojkovic, Miodrag .

STEM CELLS, 2010, 28 (03) :407-418

[6]

The Role of Circulating Bone Cell Precursors in Fracture Healing [J].

D'Amelio, Patrizia ;

Cristofaro, Maria Angela ;

Grimaldi, Anastasia ;

Ravazzoli, Marco ;

Pluviano, Fernanda ;

Grosso, Elena ;

Pescarmona, Gian Piero ;

Isaia, Giovanni Carlo .

CALCIFIED TISSUE INTERNATIONAL, 2010, 86 (06) :463-469

[7]

Cytotherapy of osteonecrosis of the femoral head: a mini review [J].

Gao, You-Shui ;

Zhang, Chang-Qing .

INTERNATIONAL ORTHOPAEDICS, 2010, 34 (06) :779-782

[8]

Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells [J].

Yoshida, Yoshinori ;

Takahashi, Kazutoshi ;

Okita, Keisuke ;

Ichisaka, Tomoko ;

Yamanaka, Shinya .

CELL STEM CELL, 2009, 5 (03) :237-241

[9]

Mechanisms of bone repair and regeneration [J].

Deschaseaux, Frederic ;

Sensebe, Luc ;

Heymann, Dominique .

TRENDS IN MOLECULAR MEDICINE, 2009, 15 (09) :417-429

[10]

Healing of a clavicle fracture nonunion with bone marrow injection.[J].Patrice Tétreault;Hugue A. Ouellette.Journal of Shoulder and Elbow Surgery.2007, 1

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