白细胞介素12在伯氏疟原虫红细胞内期感染中的免疫调节作用

被引：5

作者：

陈姝

陆惠民

张山鹰

高琪

唐学恒

孙臻安

机构：

[1] 苏州大学医学院寄生虫学教研室

[2] 福建省疾病预防控制中心

[3] 江苏省寄生虫病防治研究所

[4] 苏州大学医学院寄生虫学教研室江苏

[5] 江苏

[6] 福州

[7] 无锡

来源：

海峡预防医学杂志 | 2004年 / 01期

关键词：

白细胞介素12; 伯氏疟原虫; 红细胞内期; 免疫保护; 毒副反应;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

[目的 ]探讨白细胞介素 12 (IL 12 )在伯氏疟原虫 (P berghei)红细胞内期感染中的免疫调节作用。[方法 ]BALB/c小鼠接种 5× 10 5个感染P berghei的RBC ,分别以不同剂量 ( 0 0 1、0 0 3、0 10和 0 15 μg/d)IL 12 ,或分别在不同给药时间 (感染前 1d、感染同时、感染后第 3d)给予 0 0 3 μg/dIL 12 ,各组均连续用药 6d。观察各组小鼠原虫血症变化及存活时间。[结果 ]与对照组比较 ,较低剂量 ( 0 0 1或 0 0 3 μg/d)IL 12均可显著推迟血中原虫的出现及原虫血症达峰值的时间 ,但仅 0 0 3 μg/d剂量可明显提高生存率 ;较惯剂量 ( 0 1或 0 15 μg/d)IL 12则增加原虫密度 ,加速小鼠死亡。在感染的第 3d给予 0 0 3 μg/dIL 12 ,对原虫血症、生存率均无明显影响。IL 12不能改变感染的结局 ,最终各组小鼠均死亡。[结论 ]IL 12具有免疫保护和毒副反应双重活性。诱导保护作用而减少毒副作用 ,剂量及给药时间是关键 ,适时地给予适当剂量的IL 12可诱导抗红内期疟原虫的部分保护作用。

引用

页码：1 / 4

页数：4

共 13 条

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