抑郁症的生物学机制研究进展

被引：62

作者：

郭雨欣

邢国刚

机构：

[1] 北京大学神经科学研究所基础医学院神经生物学系教育部和卫生部神经科学重点实验室

来源：

中国神经精神疾病杂志 | 2012年 / 38卷 / 01期

基金：

北京市自然科学基金;

关键词：

抑郁症; 单胺; 基因-环境相互作用; 神经发生; 神经可塑性;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100204 [神经病学];

摘要：

<正>抑郁症是一种常见的心境障碍,其核心症状为情绪低落、思维迟缓、意志活动减退,还可能出现睡眠障碍、反复自杀念头等。据WHO统计,目前全球约有1.21亿抑郁症患者,每年有850,000人的死亡与抑郁相关。抑郁症的遗传率约为30%

引用

页码：57 / 60

页数：4

共 13 条

[1]

Epigenetics and depression: current challenges and new therapeutic options [J].

Schroeder, Marc ;

Krebs, Marie O. ;

Bleich, Stefan ;

Frieling, Helge .

CURRENT OPINION IN PSYCHIATRY, 2010, 23 (06) :588-592

[2]

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression [J].

Miller, Andrew H. ;

Maletic, Vladimir ;

Raison, Charles L. .

BIOLOGICAL PSYCHIATRY, 2009, 65 (09) :732-741

[3]

Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene [J].

Roth, Tania L. ;

Lubin, Farah D. ;

Funk, Adam J. ;

Sweatt, J. David .

BIOLOGICAL PSYCHIATRY, 2009, 65 (09) :760-769

[4]

Neuronal plasticity: A link between stress and mood disorders.[J].Francesca Calabrese;Raffaella Molteni;Giorgio Racagni;Marco A. Riva.Psychoneuroendocrinology.2009,

[5]

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression [J].

David, Denis J. ;

Samuels, Benjamin Adam ;

Rainer, Quentin ;

Wang, Jing-Wen ;

Marsteller, Douglas ;

Mendez, Indira ;

Drew, Michael ;

Craig, Douglas A. ;

Guiard, Bruno P. ;

Guilloux, Jean-Philippe ;

Artymyshyn, Roman P. ;

Gardier, Alain M. ;

Gerald, Christophe ;

Antonijevic, Irina A. ;

Leonardo, E. David ;

Hen, Rene .

NEURON, 2009, 62 (04) :479-493

[6]

Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal [J].

Surget, Alexandre ;

Saxe, Michael ;

Leman, Samuel ;

Ibarguen-Vargas, Yadira ;

Chalon, Sylvie ;

Griebel, Guy ;

Hen, Rene ;

Belzung, Catherine .

BIOLOGICAL PSYCHIATRY, 2008, 64 (04) :293-301

[7]

Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans [J].

Bryclon, Lena ;

Harrison, Neil A. ;

Walker, Cicely ;

Steptoe, Andrew ;

Critchley, Hugo D. .

BIOLOGICAL PSYCHIATRY, 2008, 63 (11) :1022-1029

[8]

Long-term plasticity of visually evoked potentials in humans is altered in major depression [J].

Normann, Claus ;

Schmitz, Daniela ;

Fuermaier, Andrea ;

Doeing, Carsten ;

Bach, Michael .

BIOLOGICAL PSYCHIATRY, 2007, 62 (05) :373-380

[9]

Signs of apoptosis of immunocompetent cells in patients with depression [J].

Ivanova S.A. ;

Semke V.Ya. ;

Vetlugina T.P. ;

Rakitina N.M. ;

Kudyakova T.A. ;

Simutkin G.G. .

Neuroscience and Behavioral Physiology, 2007, 37 (5) :527-530

[10]

Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: a pilot open-label study [J].

Mendlewicz, Julien ;

Kriwin, Philippe ;

Oswald, Pierre ;

Souery, Daniel ;

Alboni, Silvia ;

Brunello, Nicoletta .

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 2006, 21 (04) :227-231

← 1 2 →