血管内皮生长因子C及其受体表达与乳腺癌淋巴结转移的相关性研究

被引：5

作者：

李佳宇

机构：

[1] 沈阳市第四人民医院第一干诊内科

来源：

临床和实验医学杂志 | 2007年 / 05期

关键词：

乳腺癌; 血管内皮生长因子C(VEGF-C); 血管内皮生长因子C受体(VEGFR-3); 淋巴转移;

D O I：

暂无

中图分类号：

R737.9 [乳腺肿瘤];

学科分类号：

摘要：

目的检测乳腺癌组织中血管内皮生长因子c/血管内皮生长因子受体-3(VEGF-C/VEGFR-3)、淋巴管密度(LVD)的表达情况,探讨其表达水平淋巴结转移的相互关系,进一步研究肿瘤转移的机制,为抗淋巴管形成、进而为抗乳腺癌淋巴转移的治疗提供理论依据。方法应用免疫组织化学(SP)法检测83例乳腺癌手术标本的原发灶的VEGF-C及其受体VEGFR-3的表达及LVD。结果83例乳腺癌组织VEGF-C阳性表达者36例(43.3%),淋巴结转移组的VEGF-C阳性表达率为54.6%(24/44),显著高于无淋巴结转移组30.8%(12/39),(P<0.05);在VEGF-C表达阳性组、阴性组中LVD统计学上差异显著(P<0.05)。结论乳腺癌组织VEGF-C表达可能促进肿瘤内淋巴管的生成;乳腺癌的淋巴结转移和VEGF-C的高表达密切相关;。

引用

页码：7 / 8

页数：2

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