白三烯调节剂与支气管哮喘药物治疗研究进展

被引:11
作者
何慕芝 [1 ]
蔡闯 [2 ]
钟南山 [2 ]
机构
[1] 广州军区广州总医院干部病房一科
[2] 广州呼吸疾病研究所
关键词
白三烯调节剂; 孟鲁司特; 支气管哮喘; 药物治疗;
D O I
暂无
中图分类号
R562.25 [];
学科分类号
1002 ; 100201 ;
摘要
以孟鲁司特(Mont)为主要代表的白三烯调节剂,主要用于轻度持续哮喘的单药治疗以及中重度持续哮喘的辅助治疗,尤其适用于哮喘合并过敏性鼻炎及运动性哮喘的治疗。晚近研究表明,Mont可替代吸入性糖皮质激素(ICS)对ICS控制不佳的轻度持续哮喘取得满意疗效;对ICS及ICS、长效β受体激动剂联合治疗未能有效控制的中重度哮喘,Mont辅助治疗能提高患者哮喘控制测试评分,改善肺功能、提高患者哮喘生活质量积分。Mont的安全性与空白安慰剂相当,哮喘孕妇服用Mont未增加胎儿致畸风险;其治疗依从性显著高于ICS,目前没有证据支持Mont与变应性肉芽肿病及自杀有因果联系。
引用
收藏
页码:372 / 375
页数:4
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