Toll样受体4配体的研究进展

被引：37

作者：

朱雪坤 ^{[1
,2
]}

杨日芳 ^{[2
]}

孟艳秋 ^{[1
]}

机构：

[1] 沈阳化工大学制药与生物工程学院

[2] 军事医学科学院毒物药物研究所

来源：

中国药理学与毒理学杂志 | 2016年 / 30卷 / 04期

关键词：

Toll样受体4; 配体; 脂多糖; 天然免疫;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

Toll样受体4(TLR4)是TLR超家族的一员,主要识别细菌内毒素、革兰阴性菌细胞壁成分脂多糖和脂寡糖等物质,防止微生物入侵。TLR4被配体激活后可产生促炎症细胞因子和炎症趋化因子,调节天然免疫反应,但其异常调节会引发自身免疫性疾病。本文综述了TLR4的生物结构和配体识别机制和近几年对TLR4有调节作用的脂质A类似物、天然产物和合成小分子化合物的研究进展,讨论了配体的构效关系和复合物中配体-受体与蛋白质-蛋白质相互作用。

引用

页码：389 / 396

页数：8

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