慢加急性肝衰竭患者外周血CD8+T细胞中CXCR3的表达及意义

被引：8

作者：

叶一农 ^{[1
]}

赵琦毅 ^{[2
]}

周惠玲 ^{[1
]}

严海明 ^{[1
]}

张青森 ^{[1
]}

彭亮 ^{[2
]}

机构：

[1] 广东省佛山市第一人民医院感染科

[2] 中山大学附属第三医院感染性疾病科

来源：

广东医学 | 2015年 / 36卷 / 15期

关键词：

乙型肝炎; 肝衰竭; 调节性免疫; 趋化因子受体3;

D O I：

10.13820/j.cnki.gdyx.2015.15.027

中图分类号：

R575.3 [肝功能衰竭]; R512.62 [];

学科分类号：

100201 [内科学];

摘要：

目的探讨慢加急性肝衰竭(ACLF)患者CD8+T细胞上趋化因子受体3(CXCR3)的表达及与转归的关系。方法选择22例ACLF患者、18例普通慢性乙型肝炎(CHB)患者和20例健康志愿者。入院初收集血样,流式细胞仪检测外周血CD8+T细胞上CXCR3的表达。结果 ACLF患者中12例存活。CHB患者CXCR3+CD8+T细胞计数(70.31±38.07)×106·L-1,明显高于健康志愿者的(34.26±22.30)×106·L-1和ACLF患者的(10.63±8.57)×106·L-1,差异有统计学意义(P<0.05)。CXCR3+CD8+T细胞数量与ln ALT、ln AST或总胆红素水平无明显相关性。存活的ACLF患者CXCR3+CD8+T细胞计数(14.40±9.35)×106·L-1,明显高于死亡患者的(6.10±4.78)×106·L-1,差异有统计学意义(P=0.021)。结论 ACLF患者外周血CXCR3+CD8+T细胞的计数下降,并且可能与转归相关。

引用

页码：2356 / 2361

页数：6

共 9 条

[1]

Upregulation of CXCR3 expression on CD8+ T cells due to the pervasive influence of chronic hepatitis B and C virus infection [J].

de Niet, A. ;

de Bruijne, J. ;

Plat-Sinnige, M. J. Tempelmans ;

Takkenberg, R. B. ;

van Lier, R. A. W. ;

Reesink, H. W. ;

van Leeuwen, E. M. M. .

HUMAN IMMUNOLOGY, 2013, 74 (08) :899-906

[2]

The regulation of T-cell recruitment to the human liver during acute liver failure [J].

Tuncer, Ceren ;

Oo, Ye H. ;

Murphy, Nick ;

Adams, David H. ;

Lalor, Patricia F. .

LIVER INTERNATIONAL, 2013, 33 (06) :852-863

[3]

CXCR3 expression on peripheral CD4+ T cells as a predictive marker of response to treatment in chronic hepatitis C [J].

Perney, Pascal ;

Turriere, Chrystell ;

Portales, Pierre ;

Rigole, Helene ;

Psomas, Christina ;

Blanc, Francois ;

Clot, Jacques ;

Corbeau, Pierre .

CLINICAL IMMUNOLOGY, 2009, 132 (01) :55-62

[4]

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL) [J].

Sarin, Shiv Kumar ;

Kumar, Ashish ;

Almeida, John A. ;

Chawla, Yogesh Kumar ;

Fan, Sheung Tat ;

Garg, Hitendra ;

de Silva, H. Janaka ;

Hamid, Saeed Sadiq ;

Jalan, Rajiv ;

Komolmit, Piyawat ;

Lau, George K. ;

Liu, Qing ;

Madan, Kaushal ;

Mohamed, Rosmawati ;

Ning, Qin ;

Rahman, Salimur ;

Rastogi, Archana ;

Riordan, Stephen M. ;

Sakhuja, Puja ;

Samuel, Didier ;

Shah, Samir ;

Sharma, Barjesh Chander ;

Sharma, Praveen ;

Takikawa, Yasuhiro ;

Thapa, Babu Ram ;

Wai, Chun-Tao ;

Yuen, Man-Fung .

HEPATOLOGY INTERNATIONAL, 2009, 3 (01) :269-282

[5]

CD8 + T Cells Promote Inflammation and Apoptosis in the Liver after Sepsis.[J].Doreen E. Wesche-Soldato;Chun-Shiang Chung;Stephen H. Gregory;Thais P. Salazar-Mather;Carol A. Ayala;Alfred Ayala.The American Journal of Pathology.2007, 1

[6]

The role of CCR5/CXCR3 expressing CD8+cells in liver damage and viral control during persistent hepatitis C virus infection [J].

Larrubia, Juan-Ramon ;

Calvino, Miryam ;

Benito-Martinez, Selma ;

Sanz-de-Villalobos, Eduardo ;

Perna, Cristian ;

Perez-Hornedo, Jaime ;

González-Mateos, Fernando ;

Garcia-Garzon, Silvia ;

Bienvenido, Antonio ;

Parra, Trinidad .

JOURNAL OF HEPATOLOGY, 2007, 47 (05) :632-641

[7]

Patients with acute on chronic liver failure display ‘sepsis-like’ immune paralysis.[J]..Journal of Hepatology.2004, 2

[8]

Role of activated CD8+ T cells in the initiation and continuation of hepatic damage [J].

Jerrells, TR .

ALCOHOL, 2002, 27 (01) :47-52

[9]

Liver-infiltrating lymphocytes in end-stage hepatitis C virus: Subsets; activation status; and chemokine receptor phenotypes.[J].Judie Boisvert;Eric J. Kunkel;James J. Campbell;Emmet B. Keeffe;Eugene C. Butcher;Harry B. Greenberg.Journal of Hepatology.2002, 1

← 1 →