乌司他丁在肝脏缺血再灌注损伤中的作用

被引：13

作者：

魏志刚

赵浩亮

李辉宇

韩振国

机构：

[1] 山西医科大学第一医院

来源：

山西医药杂志 | 2007年 / 11期

关键词：

肝; 再灌注损伤; 线粒体,肝; 乌司他丁;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的探讨乌司他丁在肝脏缺血再灌注损伤中对线粒体的作用。方法采用健康杂交狗全肝缺血再灌注模型,检测肝功能、线粒体Na+-K+-ATP酶活性及电镜观察线粒体形态的变化。结果实验组缺血15min后Na+-K+-ATP酶活性为0.128±0.012,而对照组为0.089±0.011(P<0.05);再灌注1h后实验组Na+-K+-ATP酶活性为0.121±0.011,对照组为0.092±0.025(P<0.05)。实验组线粒体结构损伤较对照组明显减轻。结论乌司他丁在肝脏缺血再灌注损伤中对线粒体有明显保护作用,其机制是稳定线粒体膜结构及增强线粒体Na+-K+-ATP酶活性。

引用

页码：977 / 979

页数：3

共 11 条

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