TM6SF2基因rs58542926多态性与肝细胞损伤和肝纤维化严重程度相关性的Meta分析

被引：6

作者：

石明巧 ^{[1
]}

陈捷 ^{[2
]}

王兰兰 ^{[2
]}

廖云 ^{[2
]}

张琦 ^{[2
]}

严琳 ^{[2
]}

刘新乐 ^{[2
]}

机构：

[1] 四川大学华西临床医学院

[2] 四川大学华西医院实验医学科

来源：

中国循证医学杂志 | 2016年 / 16卷 / 06期

关键词：

TM6SF2; 肝纤维化; 脂代谢; 非酒精性脂肪性肝病; Meta分析;

D O I：

暂无

中图分类号：

R575.2 [肝硬变];

学科分类号：

100201 [内科学];

摘要：

目的系统评价TM6SF2基因突变与肝细胞损伤及纤维化严重程度的相关性。方法计算机检索Pub Med、CNKI、Wan Fang Data和CBM数据库,搜集有关TM6SF2基因多态性与肝纤维化以及肝细胞损伤相关性的横断面研究,检索时限均为建库至2016年1月27。由两位研究者独立筛选文献、提取资料,并评价纳入研究的方法学质量后,采用Stata 12.0软件进行Meta分析。结果最终纳入23个研究,共96 594例患者。Meta分析结果显示,在显性模型中,TM6SF2基因的变异与肝纤维化的严重程度,以及甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)水平具有显著相关性(P均<0.05)。T的携带者与C的纯合子个体相比较,其TC、TG、LDL-C的水平较低,而ALT、AST的水平较高。结论 TM6SF2的基因变异与不同人群脂质形成及代谢密切相关,突变型个体血脂含量水平较低,发生严重肝纤维化及肝损伤的风险更大。

引用

页码：655 / 662

页数：8

共 13 条

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