内肥素与儿童青少年肥胖、非酒精性脂肪肝的关联研究

被引：4

作者：

文晗

王海俊

董彬

马军

机构：

[1] 北京大学公共卫生学院/儿童青少年卫生研究所

来源：

中华流行病学杂志 | 2012年 / 03期

关键词：

内肥素; 肥胖; 脂肪肝; 儿童;

D O I：

暂无

中图分类号：

R575.5 [肝代谢障碍];

学科分类号：

100201 [内科学];

摘要：

目的探讨血清内肥素与儿童青少年肥胖、非酒精性脂肪肝(NAFLD)的关联。方法采用双抗体夹心ELISA法,测定69名体重正常无NAFLD和106名肥胖儿童青少年(肥胖无NAFLD 49名及合并NAFLD 57名,其中轻度42名、中重度15名)的血清内肥素水平。结果体重正常组与肥胖组血清内肥素水平分别为(1.75±0.37)、(1.71±0.37)ng/ml,差异无统计学意义(P=0.455);肥胖儿童青少年血清内肥素水平随着脂肪肝程度的加重而上升[肥胖无NAFLD组为(1.59±0.36)ng/ml、肥胖合并轻度NAFLD组为(1.74±0.36)ng/ml、肥胖合并中重度NAFLD组为(1.97±0.36)ng/ml,三者之间差异有统计学意义(P<0.05)],与年龄(β=-0.326,P=0.000)、丙氨酸转氨酶活性(β=0.286,P=0.004)相关,不同程度NAFLD者内肥素水平差异有统计学意义(β=0.246,P=0.014)。结论肥胖儿童青少年中血清内肥素水平与NAFLD相关。

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