脑梗死患者血清同型半胱氨酸、超敏C反应蛋白、血脂检测结果分析

被引：34

作者：

罗春华 ^{[1
]}

李国静 ^{[1
]}

刘敏 ^{[1
]}

李祖铭 ^{[2
]}

机构：

[1] 宜昌市中心人民医院检验科

[2] 宜昌市夷陵区妇幼保健院

来源：

重庆医学 | 2013年 / 42卷 / 30期

关键词：

脑梗死; 同型半胱氨酸; C反应蛋白质; 脂蛋白类; 相关性;

D O I：

暂无

中图分类号：

R743.33 [脑栓塞];

学科分类号：

1002 ;

摘要：

目的探讨不同年龄阶段脑梗死患者血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、血脂水平及其相关性。方法将322例脑梗死患者按年龄分成青年脑梗死、中年脑梗死、老年脑梗死3组,对照组为同期120例健康体检者,检测各组空腹血清Hcy、hs-CRP、血清总胆固醇(Tch)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,并对结果进行分析。结果与对照组比较,青年脑梗死组Hcy升高、HDL-C降低,差异有统计学意义(P<0.01),hs-CRP升高(P<0.05),Tch、TG、LDL-C无明显差异;中年及老年脑梗死组Hcy、hs-CRP、Tch升高,HDL-C降低,比较差异均有统计学意义(P<0.01),LDL-C升高(P<0.05),TG未见明显改变。脑梗死各年龄组Hcy、hs-CRP、HDL-C异常检出率明显高于对照组(P<0.01),中年、老年脑梗死组LDL-C异常检出率明显高于对照组(P<0.01)。脑梗死各组Hcy与血脂及hs-CRP水平未见显著相关性;hs-CRP与HDL-C呈负相关(P<0.01);Tch与TG、HDL-C及LDL-C比较差异均具有统计学意义(P<0.01)。结论血清Hcy在各年龄段脑梗死患者中均升高,高血清Hcy水平是脑卒中的独立危险因素,监测Hcy水平并对高Hcy患者进行适当干预具有重要临床价值。

引用

页码：3676 / 3678

页数：3

共 11 条

[1] 高同型半胱氨酸血症与脑梗死的相关性分析 [J].

杨国栋 ;

王士列 ;

李年春 ;

刘建平 ;

威武 ;

郑团圆 .

医学信息, 2011, 24 (01) :85-86

[2] 高同型半胱氨酸与脑梗死 [J].

荆军 .

山东医药, 2008, (01) :147-148

[3]

Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood[J]. Daniel G REMICK.Acta Pharmacologica Sinica. 2004(11)

[4] 各类脑血管疾病诊断要点 [J].

临床荟萃, 1988, (08) :367-368

[5]

Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association[J] . Karen L. Furie,Scott E. Kasner,Robert J. Adams,Gregory W. Albers,Ruth L. Bush,Susan C. Fagan,Jonathan L. Halperin,S. Claiborne Johnston,Irene Katzan,Walter N. Kernan,Pamela H. Mitchell,Bruce Ovbiagele,Yuko Y. Palesch,Ralph L. Sacco,Lee H. Schwamm,Sylvia Wassertheil-Smoller,Tanya N. Turan,Deidre

[6]

Pronounced association of elevated serum homocysteine with stroke in subgroups of individuals: A nationwide study[J] . Amytis Towfighi,Daniela Markovic,Bruce Ovbiagele.Journal of the Neurological Sciences . 2010 (1)

[7] Homocysteine reduces endothelial progenitor cells in stroke patients through apoptosis [J].

Alam, Mohammad Murshedul ;

Mohammad, Askar A. ;

Shuaib, Umar ;

Wang, Chenxu ;

Ghani, Usman ;

Schwindt, Brenda ;

Todd, Kathryn G. ;

Shuaib, Ashfaq .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2009, 29 (01) :157-165

[8]

Homocysteine and Its Relationship to Stroke Subtypes in a UK Black Population: The South London Ethnicity and Stroke Study[J] . Usman Khan,Carollyn Crossley,Lalit Kalra,Anthony Rudd,Charles D.A. Wolfe,Paul Collinson,Hugh S. Markus.Stroke . 2008 (11)

[9]

Vascular oxidative stress increases dendritic cell adhesion and transmigration induced by homocysteine[J] . Wei-guo Zhu,Shan Li,Le-qing Lin,Hui Yan,Ting Fu,Jian-hua Zhu.Cellular Immunology . 2008 (2)

[10]

Serum total homocysteine concentrations and risk of mortality from stroke and coronary heart disease in Japanese: The JACC study[J] . Renzhe Cui,Yuri Moriyama,Kazuko A. Koike,Chigusa Date,Shogo Kikuchi,Akiko Tamakoshi,Hiroyasu Iso.Atherosclerosis . 2007 (2)

← 1 2 →