类风湿关节炎流行病学进展

被引：172

作者：

叶伟胜

张铁良

机构：

[1] 天津市天津医院骨科

来源：

国际骨科学杂志 | 2009年 / 30卷 / 03期

关键词：

类风湿关节炎; 患病率; 危险因素; 死亡率;

D O I：

暂无

中图分类号：

R593.22 [类风湿性关节炎];

学科分类号：

100201 [内科学];

摘要：

类风湿关节炎(RA)的患病率随着年龄增长而逐渐增加,65岁以上或70岁以上老年人患病率最高,文化程度较低者患病率较高,女性略高于男性。成年人RA患病率为0.2%～0.8%。RA危险因素:①遗传因素:RA患者家族研究显示一级亲属患病的危险性要比无亲属关系的个体高2～4倍,双生儿研究显示当同卵双生儿中有一方患RA,另一方患病率为12%～15%。②激素及生育因素:与男性相比,RA更常见于女性;妊娠期RA常可自发缓解。③营养因素:大量摄入烘焙或烤制的鱼类,特别是富含油脂的鱼类如鲑鱼和鳟鱼,可减缓RA进展。研究显示血清中含硒水平较高可防止RA发生。④其他因素:类风湿因子检测为阳性的个体、大量吸烟,可增加发生RA的危险性,同时也增加RA进展的危险性。临床RA患者具有较高的死亡率。RA患者生存期普遍缩短3～18年,并且每经过一个10年的跨度,死亡率的总体危险性就会增加1.3～2倍。与一般人群相比,RA患者更常死于感染和心血管疾病。

引用

页码：144 / 147

页数：4

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