白介素23及Th17细胞在炎症性肠病的作用

被引：5

作者：

王明辉 ^{[1
]}

万荣 ^{[1
,2
]}

机构：

[1] 同济大学附属第十人民医院消化内科

[2] 上海交通大学附属上海第一人民医院消化内科

来源：

现代生物医学进展 | 2012年 / 12卷 / 21期

关键词：

炎症性肠病; 克罗恩病; 溃疡性结肠炎; 白细胞介素23; T辅助细胞17;

D O I：

10.13241/j.cnki.pmb.2012.21.024

中图分类号：

R574 [肠疾病];

学科分类号：

摘要：

炎症性肠病(Inflammatory Bowel Diseases,IBD),是一组病因未明的累及胃肠道的慢性炎症性疾病,一般指克罗恩病(Crohn'sdisease,CD)和溃疡性结肠炎(ulcerative colitis,UC)。目前认为它是由多种因素相互作用所致的一种自身免疫性疾病,主要包括免疫、环境以及遗传等因素,其中免疫在IBD的发生过程中起着极其重要的作用。以往研究认为与T辅助细胞(T Helper cells)Th1或Th2细胞反应的增强或减弱有关。然而最近研究发现一类新细胞亚群,称为Th17细胞,与之相关的细胞因子可导致包括肠道在内的多脏器病变。Th17细胞分化过程中又需要IL-23的参与,因此IL-23/Th17细胞在炎症性肠病患者肠道内过度表达可以解释肠组织损伤的新途径,并为制定新的治疗策略提出依据。本文就IL-23/Th17轴在炎症性肠病中的作用的研究进展作一综述。

引用

页码：4149 / 4152

页数：4

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